TY - JOUR
T1 - Purine uptake in Plasmodium
T2 - transport versus metabolism
AU - Kirk, Kiaran
AU - Howitt, Susan M.
AU - Bröer, Stefan
AU - Saliba, Kevin J.
AU - Downie, Megan J.
PY - 2009/6
Y1 - 2009/6
N2 - In a recent paper, Quashie et al. have proposed that purine uptake into the intraerythrocytic malaria parasite involves four different plasma membrane transporters - two high affinity and two low affinity. They equate one of the two high-affinity transporters with PfNT1, a transporter reported previously to be a low-affinity system. Here, we offer an alternative interpretation of their data, suggesting that the conclusions drawn by Quashie et al. take insufficient account of metabolism.
AB - In a recent paper, Quashie et al. have proposed that purine uptake into the intraerythrocytic malaria parasite involves four different plasma membrane transporters - two high affinity and two low affinity. They equate one of the two high-affinity transporters with PfNT1, a transporter reported previously to be a low-affinity system. Here, we offer an alternative interpretation of their data, suggesting that the conclusions drawn by Quashie et al. take insufficient account of metabolism.
UR - http://www.scopus.com/inward/record.url?scp=66049162097&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2009.03.006
DO - 10.1016/j.pt.2009.03.006
M3 - Comment/debate
SN - 1471-4922
VL - 25
SP - 246
EP - 249
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 6
ER -