Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Konstantin P. Tamarov, Liubov A. Osminkina, Sergey V. Zinovyev, Ksenia A. Maximova, Julia V. Kargina, Maxim B. Gongalsky, Yury Ryabchikov, Ahmed Al-Kattan, Andrey P. Sviridov, Marc Sentis, Andrey V. Ivanov, Vladimir N. Nikiforov, Andrei V. Kabashin*, Victor Yu Timoshenko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

142 Citations (Scopus)

Abstract

Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cancer cells and thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as sensitizers for the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous silicon and ultraclean laser-ablative synthesis, we report efficient RF-induced heating of aqueous suspensions of the nanoparticles to temperatures above 45-506C under relatively low nanoparticle concentrations (< 1 mg/mL) and RF radiation intensities (1-5 W/cm2). For both types of nanoparticles the heating rate was linearly dependent on nanoparticle concentration, while laser-ablated nanoparticles demonstrated a remarkably higher heating rate than porous silicon-based ones for the whole range of the used concentrations from 0.01 to 0.4 mg/mL. The observed effect is explained by the Joule heating due to the generation of electrical currents at the nanoparticle/water interface. Profiting from the nanoparticle-based hyperthermia, we demonstrate an efficient treatment of Lewis lung carcinomain vivo. Combined with the possibility of involvement of parallel imaging and treatment channels based on unique optical properties of Si-based nanomaterials, the proposed method promises a new landmark in the development of new modalities for mild cancer therapy.

Original languageEnglish
Article number7034
JournalScientific Reports
Volume4
DOIs
Publication statusPublished - 13 Nov 2014
Externally publishedYes

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