Rats: Gnawing through the barriers to understanding genetic susceptibility and breast cancer

Anneke C. Blackburn

doi:10.1186/bcr2939

Rats: Gnawing through the barriers to understanding genetic susceptibility and breast cancer

Anneke C. Blackburn^*

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › peer-review

1 Citation (Scopus)

Abstract

Advances in genotyping technology have provided us with a large number of genetic loci associated with cancer susceptibility; however, our ability to understand the functional effects of the genetic variants of these loci remains limited. In the previous issue, Smits and colleagues demonstrate the use of congenic rat strains to discover that the Mcs5a breast cancer susceptibility locus is most likely acting through the immune system, via novel transcriptional regulatory mechanisms. This challenges our conventional thinking of cancer susceptibility and gene regulation pathways, and illustrates the potential for rodent models to help us functionally characterize polymorphisms of cancer-associated loci.

Original language	English
Article number	112
Journal	Breast Cancer Research
Volume	13
Issue number	5
DOIs	https://doi.org/10.1186/bcr2939
Publication status	Published - 12 Oct 2011

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Rats: Gnawing through the barriers to understanding genetic susceptibility and breast cancer

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