Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam

Ngoc Anh Hoang; Thai Quang Pham; Ha Linh Quach; Khanh Cong Nguyen; Samantha Colquhoun; Stephen Lambert; Duong Huy Luong; Quang Dai Tran; Dinh Cong Phung; Tran Nhu Duong; Nghia Duy Ngu; Tu Anh Tran; Hue Bich Thi Nguyen; Duc Anh Dang; Florian Vogt

doi:10.5365/wpsar.2021.12.4.857

Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam

Ngoc Anh Hoang, Thai Quang Pham^*, Ha Linh Quach^*, Khanh Cong Nguyen, Samantha Colquhoun, Stephen Lambert, Duong Huy Luong, Quang Dai Tran, Dinh Cong Phung, Tran Nhu Duong, Nghia Duy Ngu, Tu Anh Tran, Hue Bich Thi Nguyen, Duc Anh Dang, Florian Vogt

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and test re-positivity after a negative test have raised concerns about the ability to effectively control the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the prevalence of COVID-19 asymptomatic and pre-symptomatic infections during the second wave of COVID-19 in Viet Nam, and to better understand the duration of SARS-CoV-2 infection and the dynamics between the evolution of clinical symptoms and SARS-CoV-2 test positivity among confirmed COVID-19 cases.

Methods: We conducted a cohort analysis on the first 50 confirmed cases during the second COVID-19 wave in Viet Nam using clinical, laboratory and epidemiological data collected from 9 March to 30 April 2020. Kaplan-Meier estimates were used to assess time to clearance of SARS-CoV-2 infection, and log-rank tests were used to explore factors related to time to SARS-CoV-2 infection clearance.

Results: Most cases (58%) had no typical signs or symptoms of COVID-19 at the time of diagnosis. Ten cases (20%) were re-positive for SARS-CoV-2 during infection. Eight cases (16%) experienced COVID-19 symptoms after testing negative for SARS-CoV-2. The median duration from symptom onset until clearance of infection was 14 days (range: 6–31); it was longer in re-positive and older patients and those with pre-existing conditions.

Conclusion: Asymptomatic and pre-symptomatic infections were common during the second wave of COVID-19 in Viet Nam. Re-positivity was frequent during hospitalization and led to a long duration of SARS-CoV-2 infection.

Original language	English
Pages (from-to)	82-92
Journal	Western Pacific Surveillance and Response Journal
Volume	12
Issue number	4
DOIs	https://doi.org/10.5365/wpsar.2021.12.4.857
Publication status	Published - Oct 2021

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Hoang, N. A., Pham, T. Q., Quach, H. L., Nguyen, K. C., Colquhoun, S., Lambert, S., Luong, D. H., Tran, Q. D., Phung, D. C., Duong, T. N., Ngu, N. D., Tran, T. A., Nguyen, H. B. T., Dang, D. A., & Vogt, F. (2021). Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam. Western Pacific Surveillance and Response Journal, 12(4), 82-92. https://doi.org/10.5365/wpsar.2021.12.4.857

@article{99c6276a0045409cb44489196f0dce2e,

title = "Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam",

abstract = "Objective: Asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and test re-positivity after a negative test have raised concerns about the ability to effectively control the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the prevalence of COVID-19 asymptomatic and pre-symptomatic infections during the second wave of COVID-19 in Viet Nam, and to better understand the duration of SARS-CoV-2 infection and the dynamics between the evolution of clinical symptoms and SARS-CoV-2 test positivity among confirmed COVID-19 cases. Methods: We conducted a cohort analysis on the first 50 confirmed cases during the second COVID-19 wave in Viet Nam using clinical, laboratory and epidemiological data collected from 9 March to 30 April 2020. Kaplan-Meier estimates were used to assess time to clearance of SARS-CoV-2 infection, and log-rank tests were used to explore factors related to time to SARS-CoV-2 infection clearance. Results: Most cases (58\%) had no typical signs or symptoms of COVID-19 at the time of diagnosis. Ten cases (20\%) were re-positive for SARS-CoV-2 during infection. Eight cases (16\%) experienced COVID-19 symptoms after testing negative for SARS-CoV-2. The median duration from symptom onset until clearance of infection was 14 days (range: 6–31); it was longer in re-positive and older patients and those with pre-existing conditions. Conclusion: Asymptomatic and pre-symptomatic infections were common during the second wave of COVID-19 in Viet Nam. Re-positivity was frequent during hospitalization and led to a long duration of SARS-CoV-2 infection.",

author = "Hoang, \{Ngoc Anh\} and Pham, \{Thai Quang\} and Quach, \{Ha Linh\} and Nguyen, \{Khanh Cong\} and Samantha Colquhoun and Stephen Lambert and Luong, \{Duong Huy\} and Tran, \{Quang Dai\} and Phung, \{Dinh Cong\} and Duong, \{Tran Nhu\} and Ngu, \{Nghia Duy\} and Tran, \{Tu Anh\} and Nguyen, \{Hue Bich Thi\} and Dang, \{Duc Anh\} and Florian Vogt",

note = "{\textcopyright}2021 The authors",

year = "2021",

month = oct,

doi = "10.5365/wpsar.2021.12.4.857",

language = "English",

volume = "12",

pages = "82--92",

journal = "Western Pacific Surveillance and Response Journal",

issn = "2094-7321",

publisher = "World Health Organization",

number = "4",

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Hoang, NA, Pham, TQ, Quach, HL, Nguyen, KC, Colquhoun, S, Lambert, S, Luong, DH, Tran, QD, Phung, DC, Duong, TN, Ngu, ND, Tran, TA, Nguyen, HBT, Dang, DA & Vogt, F 2021, 'Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam', Western Pacific Surveillance and Response Journal, vol. 12, no. 4, pp. 82-92. https://doi.org/10.5365/wpsar.2021.12.4.857

TY - JOUR

T1 - Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam

AU - Hoang, Ngoc Anh

AU - Pham, Thai Quang

AU - Quach, Ha Linh

AU - Nguyen, Khanh Cong

AU - Colquhoun, Samantha

AU - Lambert, Stephen

AU - Luong, Duong Huy

AU - Tran, Quang Dai

AU - Phung, Dinh Cong

AU - Duong, Tran Nhu

AU - Ngu, Nghia Duy

AU - Tran, Tu Anh

AU - Nguyen, Hue Bich Thi

AU - Dang, Duc Anh

AU - Vogt, Florian

PY - 2021/10

Y1 - 2021/10

N2 - Objective: Asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and test re-positivity after a negative test have raised concerns about the ability to effectively control the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the prevalence of COVID-19 asymptomatic and pre-symptomatic infections during the second wave of COVID-19 in Viet Nam, and to better understand the duration of SARS-CoV-2 infection and the dynamics between the evolution of clinical symptoms and SARS-CoV-2 test positivity among confirmed COVID-19 cases. Methods: We conducted a cohort analysis on the first 50 confirmed cases during the second COVID-19 wave in Viet Nam using clinical, laboratory and epidemiological data collected from 9 March to 30 April 2020. Kaplan-Meier estimates were used to assess time to clearance of SARS-CoV-2 infection, and log-rank tests were used to explore factors related to time to SARS-CoV-2 infection clearance. Results: Most cases (58%) had no typical signs or symptoms of COVID-19 at the time of diagnosis. Ten cases (20%) were re-positive for SARS-CoV-2 during infection. Eight cases (16%) experienced COVID-19 symptoms after testing negative for SARS-CoV-2. The median duration from symptom onset until clearance of infection was 14 days (range: 6–31); it was longer in re-positive and older patients and those with pre-existing conditions. Conclusion: Asymptomatic and pre-symptomatic infections were common during the second wave of COVID-19 in Viet Nam. Re-positivity was frequent during hospitalization and led to a long duration of SARS-CoV-2 infection.

AB - Objective: Asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and test re-positivity after a negative test have raised concerns about the ability to effectively control the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the prevalence of COVID-19 asymptomatic and pre-symptomatic infections during the second wave of COVID-19 in Viet Nam, and to better understand the duration of SARS-CoV-2 infection and the dynamics between the evolution of clinical symptoms and SARS-CoV-2 test positivity among confirmed COVID-19 cases. Methods: We conducted a cohort analysis on the first 50 confirmed cases during the second COVID-19 wave in Viet Nam using clinical, laboratory and epidemiological data collected from 9 March to 30 April 2020. Kaplan-Meier estimates were used to assess time to clearance of SARS-CoV-2 infection, and log-rank tests were used to explore factors related to time to SARS-CoV-2 infection clearance. Results: Most cases (58%) had no typical signs or symptoms of COVID-19 at the time of diagnosis. Ten cases (20%) were re-positive for SARS-CoV-2 during infection. Eight cases (16%) experienced COVID-19 symptoms after testing negative for SARS-CoV-2. The median duration from symptom onset until clearance of infection was 14 days (range: 6–31); it was longer in re-positive and older patients and those with pre-existing conditions. Conclusion: Asymptomatic and pre-symptomatic infections were common during the second wave of COVID-19 in Viet Nam. Re-positivity was frequent during hospitalization and led to a long duration of SARS-CoV-2 infection.

UR - https://www.scopus.com/pages/publications/85125831619

U2 - 10.5365/wpsar.2021.12.4.857

DO - 10.5365/wpsar.2021.12.4.857

M3 - Article

SN - 2094-7321

VL - 12

SP - 82

EP - 92

JO - Western Pacific Surveillance and Response Journal

JF - Western Pacific Surveillance and Response Journal

IS - 4

ER -

Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam

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