Reactivities of coordinated phosphodiesters

R. D. Wijesekera; A. M. Sargeson

doi:10.1080/00958970512331327393

Reactivities of coordinated phosphodiesters

R. D. Wijesekera, A. M. Sargeson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The amminolysis and hydrolysis of the ester moieties in [(NH ₃)₅Co(bnpp)]²⁺ and cis-[(en) ₂Co(OH)(bnpp)]⁺ (where bnpp = bis(4-nitrophenylphosphate) and en = 1,2-ethanediamine) in aqueous solution at 25°C have been followed over a range in pH. In each instance, cleavage of 4-nitrophenol occurred in two observable events triggered by the coordinated nucleophiles, amido ion and hydroxo ion. The mechanistic pathways have been analyzed and the rate enhancements evaluated relative to uncoordinated substrates and other relevant literature data. The analysis indicates requirements for the metal reagent to be effective in phosphate ester hydrolysis and phosphoryl transfer.

Original language	English
Pages (from-to)	3-19
Number of pages	17
Journal	Journal of Coordination Chemistry
Volume	58
Issue number	1
DOIs	https://doi.org/10.1080/00958970512331327393
Publication status	Published - 10 Jan 2005

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10.1080/00958970512331327393

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title = "Reactivities of coordinated phosphodiesters",

abstract = "The amminolysis and hydrolysis of the ester moieties in [(NH 3)5Co(bnpp)]2+ and cis-[(en) 2Co(OH)(bnpp)]+ (where bnpp = bis(4-nitrophenylphosphate) and en = 1,2-ethanediamine) in aqueous solution at 25°C have been followed over a range in pH. In each instance, cleavage of 4-nitrophenol occurred in two observable events triggered by the coordinated nucleophiles, amido ion and hydroxo ion. The mechanistic pathways have been analyzed and the rate enhancements evaluated relative to uncoordinated substrates and other relevant literature data. The analysis indicates requirements for the metal reagent to be effective in phosphate ester hydrolysis and phosphoryl transfer.",

keywords = "Cobalt, Metal ion activated phosphate ester cleavage, Phosphate ester, Phosphoryl transfer",

author = "Wijesekera, {R. D.} and Sargeson, {A. M.}",

year = "2005",

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doi = "10.1080/00958970512331327393",

language = "English",

volume = "58",

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journal = "Journal of Coordination Chemistry",

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T1 - Reactivities of coordinated phosphodiesters

AU - Wijesekera, R. D.

AU - Sargeson, A. M.

PY - 2005/1/10

Y1 - 2005/1/10

N2 - The amminolysis and hydrolysis of the ester moieties in [(NH 3)5Co(bnpp)]2+ and cis-[(en) 2Co(OH)(bnpp)]+ (where bnpp = bis(4-nitrophenylphosphate) and en = 1,2-ethanediamine) in aqueous solution at 25°C have been followed over a range in pH. In each instance, cleavage of 4-nitrophenol occurred in two observable events triggered by the coordinated nucleophiles, amido ion and hydroxo ion. The mechanistic pathways have been analyzed and the rate enhancements evaluated relative to uncoordinated substrates and other relevant literature data. The analysis indicates requirements for the metal reagent to be effective in phosphate ester hydrolysis and phosphoryl transfer.

AB - The amminolysis and hydrolysis of the ester moieties in [(NH 3)5Co(bnpp)]2+ and cis-[(en) 2Co(OH)(bnpp)]+ (where bnpp = bis(4-nitrophenylphosphate) and en = 1,2-ethanediamine) in aqueous solution at 25°C have been followed over a range in pH. In each instance, cleavage of 4-nitrophenol occurred in two observable events triggered by the coordinated nucleophiles, amido ion and hydroxo ion. The mechanistic pathways have been analyzed and the rate enhancements evaluated relative to uncoordinated substrates and other relevant literature data. The analysis indicates requirements for the metal reagent to be effective in phosphate ester hydrolysis and phosphoryl transfer.

KW - Cobalt

KW - Metal ion activated phosphate ester cleavage

KW - Phosphate ester

KW - Phosphoryl transfer

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U2 - 10.1080/00958970512331327393

DO - 10.1080/00958970512331327393

M3 - Article

SN - 0095-8972

VL - 58

SP - 3

EP - 19

JO - Journal of Coordination Chemistry

JF - Journal of Coordination Chemistry

IS - 1

ER -

Reactivities of coordinated phosphodiesters

Abstract

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