Recent advances in ion channel research

Shin Ho Chung; Serdar Kuyucak

doi:10.1016/S0005-2736(02)00574-6

Recent advances in ion channel research

Shin Ho Chung^*, Serdar Kuyucak

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

91 Citations (Scopus)

Abstract

The field of ion channels has entered into a rapid phase of development in the last few years, partly due to the breakthroughs in determination of the crystal structures of membrane proteins and advances in computer simulations of biomolecules. These advances have finally enabled the long-dreamed goal of relating function of a channel to its underlying molecular structure. Here we present simplified accounts of the competing permeation theories and then discuss their application to the potassium, gramicidin A and calcium channels.

Original language	English
Pages (from-to)	267-286
Number of pages	20
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	1565
Issue number	2
DOIs	https://doi.org/10.1016/S0005-2736(02)00574-6
Publication status	Published - 11 Oct 2002

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AB - The field of ion channels has entered into a rapid phase of development in the last few years, partly due to the breakthroughs in determination of the crystal structures of membrane proteins and advances in computer simulations of biomolecules. These advances have finally enabled the long-dreamed goal of relating function of a channel to its underlying molecular structure. Here we present simplified accounts of the competing permeation theories and then discuss their application to the potassium, gramicidin A and calcium channels.

KW - Brownian dynamics

KW - Channel modeling

KW - Membrane ion channel

KW - Molecular dynamics

KW - Theories of ion permeation

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M3 - Review article

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JO - Biochimica et Biophysica Acta - Biomembranes

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Recent advances in ion channel research

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