Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology

Ishac Nazy; Ulrich J. Sachs; Donald M. Arnold; Steven E. McKenzie; Phil Choi; Karina Althaus; Maria Therese Ahlen; Ruchika Sharma; Rachael F. Grace; Tamam Bakchoul

doi:10.1111/jth.15341

Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology

Ishac Nazy^*, Ulrich J. Sachs, Donald M. Arnold, Steven E. McKenzie, Phil Choi, Karina Althaus, Maria Therese Ahlen, Ruchika Sharma, Rachael F. Grace, Tamam Bakchoul^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

Vaccine administration is under way worldwide to combat the current COVID-19 pandemic. The newly developed vaccines are highly effective with minimal adverse effects. Recently, the AstraZeneca ChadOx1 nCov-19 vaccine has raised public alarm with concerns regarding the rare, but serious, development of thrombotic events, now known as vaccine-induced immune thrombotic thrombocytopenia (VITT). These thrombotic events appear similar to heparin-induced thrombocytopenia, both clinically and pathologically. In this manuscript, the ISTH SSC Subcommittee on Platelet Immunology outlines guidelines on how to recognize, diagnose and manage patients with VITT.

Original language	English
Pages (from-to)	1585-1588
Number of pages	4
Journal	Journal of Thrombosis and Haemostasis
Volume	19
Issue number	6
DOIs	https://doi.org/10.1111/jth.15341
Publication status	Published - Jun 2021

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Nazy, I., Sachs, U. J., Arnold, D. M., McKenzie, S. E., Choi, P., Althaus, K., Ahlen, M. T., Sharma, R., Grace, R. F., & Bakchoul, T. (2021). Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology. Journal of Thrombosis and Haemostasis, 19(6), 1585-1588. https://doi.org/10.1111/jth.15341

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title = "Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology",

abstract = "Vaccine administration is under way worldwide to combat the current COVID-19 pandemic. The newly developed vaccines are highly effective with minimal adverse effects. Recently, the AstraZeneca ChadOx1 nCov-19 vaccine has raised public alarm with concerns regarding the rare, but serious, development of thrombotic events, now known as vaccine-induced immune thrombotic thrombocytopenia (VITT). These thrombotic events appear similar to heparin-induced thrombocytopenia, both clinically and pathologically. In this manuscript, the ISTH SSC Subcommittee on Platelet Immunology outlines guidelines on how to recognize, diagnose and manage patients with VITT.",

keywords = "AstraZeneca ChadOx1 nCov-19 vaccine, COVID-19, platelet activation, thrombocytopenia, thrombosis",

author = "Ishac Nazy and Sachs, {Ulrich J.} and Arnold, {Donald M.} and McKenzie, {Steven E.} and Phil Choi and Karina Althaus and Ahlen, {Maria Therese} and Ruchika Sharma and Grace, {Rachael F.} and Tamam Bakchoul",

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year = "2021",

month = jun,

doi = "10.1111/jth.15341",

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Nazy, I, Sachs, UJ, Arnold, DM, McKenzie, SE, Choi, P, Althaus, K, Ahlen, MT, Sharma, R, Grace, RF & Bakchoul, T 2021, 'Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology', Journal of Thrombosis and Haemostasis, vol. 19, no. 6, pp. 1585-1588. https://doi.org/10.1111/jth.15341

TY - JOUR

T1 - Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19

T2 - Communication from the ISTH SSC Subcommittee on Platelet Immunology

AU - Nazy, Ishac

AU - Sachs, Ulrich J.

AU - Arnold, Donald M.

AU - McKenzie, Steven E.

AU - Choi, Phil

AU - Althaus, Karina

AU - Ahlen, Maria Therese

AU - Sharma, Ruchika

AU - Grace, Rachael F.

AU - Bakchoul, Tamam

PY - 2021/6

Y1 - 2021/6

N2 - Vaccine administration is under way worldwide to combat the current COVID-19 pandemic. The newly developed vaccines are highly effective with minimal adverse effects. Recently, the AstraZeneca ChadOx1 nCov-19 vaccine has raised public alarm with concerns regarding the rare, but serious, development of thrombotic events, now known as vaccine-induced immune thrombotic thrombocytopenia (VITT). These thrombotic events appear similar to heparin-induced thrombocytopenia, both clinically and pathologically. In this manuscript, the ISTH SSC Subcommittee on Platelet Immunology outlines guidelines on how to recognize, diagnose and manage patients with VITT.

AB - Vaccine administration is under way worldwide to combat the current COVID-19 pandemic. The newly developed vaccines are highly effective with minimal adverse effects. Recently, the AstraZeneca ChadOx1 nCov-19 vaccine has raised public alarm with concerns regarding the rare, but serious, development of thrombotic events, now known as vaccine-induced immune thrombotic thrombocytopenia (VITT). These thrombotic events appear similar to heparin-induced thrombocytopenia, both clinically and pathologically. In this manuscript, the ISTH SSC Subcommittee on Platelet Immunology outlines guidelines on how to recognize, diagnose and manage patients with VITT.

KW - AstraZeneca ChadOx1 nCov-19 vaccine

KW - COVID-19

KW - platelet activation

KW - thrombocytopenia

KW - thrombosis

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U2 - 10.1111/jth.15341

DO - 10.1111/jth.15341

M3 - Article

SN - 1538-7933

VL - 19

SP - 1585

EP - 1588

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 6

ER -

Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology

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