Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex

Katherine Belov; Janine E. Deakin; Anthony T. Papenfuss; Michelle L. Baker; Sandra D. Melman; Hannah V. Siddle; Nicolas Gouin; David L. Goode; Tobias J. Sargeant; Mark D. Robinson; Matthew J. Wakefield; Shaun Mahony; Joseph G.R. Cross; Panayiotis V. Benos; Paul B. Samollow; Terence P. Speed; Jennifer A. Marshall Graves; Robert D. Miller

doi:10.1371/journal.pbio.0040046

Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex

Katherine Belov^*, Janine E. Deakin, Anthony T. Papenfuss, Michelle L. Baker, Sandra D. Melman, Hannah V. Siddle, Nicolas Gouin, David L. Goode, Tobias J. Sargeant, Mark D. Robinson, Matthew J. Wakefield, Shaun Mahony, Joseph G.R. Cross, Panayiotis V. Benos, Paul B. Samollow, Terence P. Speed, Jennifer A. Marshall Graves, Robert D. Miller

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used the Monodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC of birds. Here we show that the opossum MHC is gene dense and complex, as in humans, but shares more organizational features with non-mammals. The Class I genes have amplified within the Class II region, resulting in a unique Class I/II region. We present a model of the organization of the MHC in ancestral mammals and its elaboration during mammalian evolution. The opossum genome, together with other extant genomes, reveals the existence of an ancestral "immune supercomplex" that contained genes of both types of natural killer receptors together with antigen processing genes and MHC genes. Copyright:

Original language	English
Pages (from-to)	317-328
Number of pages	12
Journal	PLoS Biology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1371/journal.pbio.0040046
Publication status	Published - Mar 2006

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Belov, K., Deakin, J. E., Papenfuss, A. T., Baker, M. L., Melman, S. D., Siddle, H. V., Gouin, N., Goode, D. L., Sargeant, T. J., Robinson, M. D., Wakefield, M. J., Mahony, S., Cross, J. G. R., Benos, P. V., Samollow, P. B., Speed, T. P., Marshall Graves, J. A., & Miller, R. D. (2006). Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. PLoS Biology, 4(3), 317-328. https://doi.org/10.1371/journal.pbio.0040046

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title = "Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex",

abstract = "The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used the Monodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC of birds. Here we show that the opossum MHC is gene dense and complex, as in humans, but shares more organizational features with non-mammals. The Class I genes have amplified within the Class II region, resulting in a unique Class I/II region. We present a model of the organization of the MHC in ancestral mammals and its elaboration during mammalian evolution. The opossum genome, together with other extant genomes, reveals the existence of an ancestral {"}immune supercomplex{"} that contained genes of both types of natural killer receptors together with antigen processing genes and MHC genes. Copyright:",

author = "Katherine Belov and Deakin, {Janine E.} and Papenfuss, {Anthony T.} and Baker, {Michelle L.} and Melman, {Sandra D.} and Siddle, {Hannah V.} and Nicolas Gouin and Goode, {David L.} and Sargeant, {Tobias J.} and Robinson, {Mark D.} and Wakefield, {Matthew J.} and Shaun Mahony and Cross, {Joseph G.R.} and Benos, {Panayiotis V.} and Samollow, {Paul B.} and Speed, {Terence P.} and {Marshall Graves}, {Jennifer A.} and Miller, {Robert D.}",

year = "2006",

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Belov, K, Deakin, JE, Papenfuss, AT, Baker, ML, Melman, SD, Siddle, HV, Gouin, N, Goode, DL, Sargeant, TJ, Robinson, MD, Wakefield, MJ, Mahony, S, Cross, JGR, Benos, PV, Samollow, PB, Speed, TP, Marshall Graves, JA & Miller, RD 2006, 'Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex', PLoS Biology, vol. 4, no. 3, pp. 317-328. https://doi.org/10.1371/journal.pbio.0040046

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AU - Cross, Joseph G.R.

AU - Benos, Panayiotis V.

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Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex

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