Abstract
The generation of genetically modified alleles in mice using conventional transgenesis technologies is a long and inefficient process. A new study shows that the in situ delivery of CRISPR/Cas9 reagents into pregnant mice results in a high efficiency of editing, and enables the rapid generation of both simple and complex alleles.
Original language | English |
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Article number | 27 |
Journal | Genome Biology |
Volume | 19 |
Issue number | 1 |
DOIs | |
Publication status | Published - 28 Feb 2018 |