Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology

Gaetan Burgio*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)


    The generation of genetically modified alleles in mice using conventional transgenesis technologies is a long and inefficient process. A new study shows that the in situ delivery of CRISPR/Cas9 reagents into pregnant mice results in a high efficiency of editing, and enables the rapid generation of both simple and complex alleles.

    Original languageEnglish
    Article number27
    JournalGenome Biology
    Issue number1
    Publication statusPublished - 28 Feb 2018


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