TY - JOUR
T1 - Regional Metastasis in Head and Neck Cutaneous Squamous Cell Carcinoma
T2 - An Update on the Significance of Extra-Nodal Extension and Soft Tissue Metastasis
AU - Hasmat, Shaheen
AU - Mooney, Craig
AU - Gao, Kan
AU - Palme, Carsten E.
AU - Ebrahimi, Ardalan
AU - Ch’ng, Sydney
AU - Gupta, Ruta
AU - Low, Tsu Hui
AU - Clark, Jonathan
N1 - Publisher Copyright:
© 2020, Society of Surgical Oncology.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background: Soft tissue metastases (STMs) are reported to predict worse prognosis than extra-nodal extension (ENE) in metastatic head and neck cutaneous squamous cell carcinoma. This study aimed to update the authors’ previous analysis of STM in a larger series. Methods: The study analyzed 535 cases of consecutive cSCC metastatic to the parotid and/or neck treated by primary surgical resection between 1987 and 2007. A Cox proportional hazard model was used to determine the effect of STM, with adjustment for other relevant prognostic factors. Overall survival (OS) and disease-specific survival (DSS) were the primary end points. Results: Of the 535 patients, 275 (51.4%) had STM. After adjustment for the effects of age, tumor location, number of metastatic deposits, and adjuvant radiotherapy, both STM (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.08–2.22; p = 0.018) and ENE (HR, 1.56; 95% CI 1.10–2.22; p = 0.013) were shown to be independent predictors of reduced OS, with similar size of effect. Conclusion: In metastatic cSCC of the head and neck, STM is an independent predictor of reduced survival and has an impact on survival similar to that of ENE.
AB - Background: Soft tissue metastases (STMs) are reported to predict worse prognosis than extra-nodal extension (ENE) in metastatic head and neck cutaneous squamous cell carcinoma. This study aimed to update the authors’ previous analysis of STM in a larger series. Methods: The study analyzed 535 cases of consecutive cSCC metastatic to the parotid and/or neck treated by primary surgical resection between 1987 and 2007. A Cox proportional hazard model was used to determine the effect of STM, with adjustment for other relevant prognostic factors. Overall survival (OS) and disease-specific survival (DSS) were the primary end points. Results: Of the 535 patients, 275 (51.4%) had STM. After adjustment for the effects of age, tumor location, number of metastatic deposits, and adjuvant radiotherapy, both STM (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.08–2.22; p = 0.018) and ENE (HR, 1.56; 95% CI 1.10–2.22; p = 0.013) were shown to be independent predictors of reduced OS, with similar size of effect. Conclusion: In metastatic cSCC of the head and neck, STM is an independent predictor of reduced survival and has an impact on survival similar to that of ENE.
UR - http://www.scopus.com/inward/record.url?scp=85079792318&partnerID=8YFLogxK
U2 - 10.1245/s10434-020-08252-9
DO - 10.1245/s10434-020-08252-9
M3 - Article
SN - 1068-9265
VL - 27
SP - 2840
EP - 2845
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 8
ER -