Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents

Mohamed Fares; Patrick M. McCosker; Muhammad A. Alsherbiny; Anthony C. Willis; Timothy Clark; Johan Neyts; Dirk Jochmans; Paul A. Keller

doi:10.1039/d0ra00257g

Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents

Mohamed Fares^*, Patrick M. McCosker, Muhammad A. Alsherbiny, Anthony C. Willis, Timothy Clark, Johan Neyts, Dirk Jochmans, Paul A. Keller

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.

Original language	English
Pages (from-to)	5191-5195
Number of pages	5
Journal	RSC Advances
Volume	10
Issue number	9
DOIs	https://doi.org/10.1039/d0ra00257g
Publication status	Published - 2020

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title = "Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents",

abstract = "Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.",

author = "Mohamed Fares and McCosker, {Patrick M.} and Alsherbiny, {Muhammad A.} and Willis, {Anthony C.} and Timothy Clark and Johan Neyts and Dirk Jochmans and Keller, {Paul A.}",

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year = "2020",

doi = "10.1039/d0ra00257g",

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T2 - A] pyrimidines as potential anti-chikungunya agents

AU - Fares, Mohamed

AU - McCosker, Patrick M.

AU - Alsherbiny, Muhammad A.

AU - Willis, Anthony C.

AU - Clark, Timothy

AU - Neyts, Johan

AU - Jochmans, Dirk

AU - Keller, Paul A.

PY - 2020

Y1 - 2020

N2 - Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.

AB - Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.

UR - http://www.scopus.com/inward/record.url?scp=85079352028&partnerID=8YFLogxK

U2 - 10.1039/d0ra00257g

DO - 10.1039/d0ra00257g

M3 - Article

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VL - 10

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JO - RSC Advances

JF - RSC Advances

IS - 9

ER -

Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents

Abstract

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