Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains

Arturo Bravo-Nuevo; Neal K. Williams; Krisztina Valter; Jonathan Stone

doi:10.1016/j.mito.2007.05.003

Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains

Arturo Bravo-Nuevo, Neal K. Williams, Krisztina Valter, Jonathan Stone^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In this study, we used Real-Time PCR to study the correlation of mtDNA deletions and photoreceptor death by apoptosis in one normal (SD) and two different degenerative (RCS and P23H) rat strains. Our results show that, in the SD and RCS strains, mtDNA deletion frequency increased and fell during neonatal life, correlating with rates of photoreceptor death during the critical period of photoreceptor development, and into adulthood. Results suggest that mitochondrial damage occurs in close association with photoreceptor death, in the normal (SD) and fast degenerative (RCS) retinas. The lack of a similar association was observed in the slowly degenerative P23H-3 strain.

Original language	English
Pages (from-to)	340-346
Number of pages	7
Journal	Mitochondrion
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/j.mito.2007.05.003
Publication status	Published - Sept 2007

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title = "Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains",

abstract = "In this study, we used Real-Time PCR to study the correlation of mtDNA deletions and photoreceptor death by apoptosis in one normal (SD) and two different degenerative (RCS and P23H) rat strains. Our results show that, in the SD and RCS strains, mtDNA deletion frequency increased and fell during neonatal life, correlating with rates of photoreceptor death during the critical period of photoreceptor development, and into adulthood. Results suggest that mitochondrial damage occurs in close association with photoreceptor death, in the normal (SD) and fast degenerative (RCS) retinas. The lack of a similar association was observed in the slowly degenerative P23H-3 strain.",

keywords = "4834 kb deletion, Hypoxia, Mitochondrial DNA deletions, Retina, Retinal degenerations",

author = "Arturo Bravo-Nuevo and Williams, {Neal K.} and Krisztina Valter and Jonathan Stone",

year = "2007",

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T1 - Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains

AU - Bravo-Nuevo, Arturo

AU - Williams, Neal K.

AU - Valter, Krisztina

AU - Stone, Jonathan

PY - 2007/9

Y1 - 2007/9

N2 - In this study, we used Real-Time PCR to study the correlation of mtDNA deletions and photoreceptor death by apoptosis in one normal (SD) and two different degenerative (RCS and P23H) rat strains. Our results show that, in the SD and RCS strains, mtDNA deletion frequency increased and fell during neonatal life, correlating with rates of photoreceptor death during the critical period of photoreceptor development, and into adulthood. Results suggest that mitochondrial damage occurs in close association with photoreceptor death, in the normal (SD) and fast degenerative (RCS) retinas. The lack of a similar association was observed in the slowly degenerative P23H-3 strain.

AB - In this study, we used Real-Time PCR to study the correlation of mtDNA deletions and photoreceptor death by apoptosis in one normal (SD) and two different degenerative (RCS and P23H) rat strains. Our results show that, in the SD and RCS strains, mtDNA deletion frequency increased and fell during neonatal life, correlating with rates of photoreceptor death during the critical period of photoreceptor development, and into adulthood. Results suggest that mitochondrial damage occurs in close association with photoreceptor death, in the normal (SD) and fast degenerative (RCS) retinas. The lack of a similar association was observed in the slowly degenerative P23H-3 strain.

KW - 4834 kb deletion

KW - Hypoxia

KW - Mitochondrial DNA deletions

KW - Retina

KW - Retinal degenerations

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DO - 10.1016/j.mito.2007.05.003

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SN - 1567-7249

VL - 7

SP - 340

EP - 346

JO - Mitochondrion

JF - Mitochondrion

IS - 5

ER -

Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains

Abstract

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