Residue-Specific Peptide Modification: A Chemist's Guide

Justine N. DeGruyter, Lara R. Malins, Phil S. Baran*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

388 Citations (Scopus)

Abstract

Advances in bioconjugation and native protein modification are appearing at a blistering pace, making it increasingly time consuming for practitioners to identify the best chemical method for modifying a specific amino acid residue in a complex setting. The purpose of this perspective is to provide an informative, graphically rich manual highlighting significant advances in the field over the past decade. This guide will help triage candidate methods for peptide alteration and will serve as a starting point for those seeking to solve long-standing challenges.

Original languageEnglish
Pages (from-to)3863-3873
Number of pages11
JournalBiochemistry
Volume56
Issue number30
DOIs
Publication statusPublished - 1 Aug 2017
Externally publishedYes

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