TY - JOUR
T1 - Restricted Semliki Forest virus replication in perforin and Fas-ligand double-deficient mice
AU - Alsharifi, Mohammed
AU - Lobigs, Mario
AU - Bettadapura, Jayaram
AU - Koskinen, Aulikki
AU - Müllbacher, Arno
PY - 2008/8
Y1 - 2008/8
N2 - Previously, we have shown that mice defective in granule exocytosis and/ or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf-/-xg/d) relative to that in wild-type counterparts and found that viral replication in perf-/-xg/d mice is remarkably restricted. Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated.
AB - Previously, we have shown that mice defective in granule exocytosis and/ or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf-/-xg/d) relative to that in wild-type counterparts and found that viral replication in perf-/-xg/d mice is remarkably restricted. Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated.
UR - http://www.scopus.com/inward/record.url?scp=50549102881&partnerID=8YFLogxK
U2 - 10.1099/vir.0.83626-0
DO - 10.1099/vir.0.83626-0
M3 - Article
SN - 0022-1317
VL - 89
SP - 1942
EP - 1944
JO - Journal of General Virology
JF - Journal of General Virology
IS - 8
ER -