Retinal ganglion cells electrophysiology: The effect of cell morphology on impulse waveform

Matias I. Maturana; Raymond Wong; Shaun L. Cloherty; Michael R. Ibbotson; Alex E. Hadjinicolaou; David B. Grayden; Anthony N. Burkitt; Hamish Meffin; Brendan J. O'Brien; Tatiana Kameneva

doi:10.1109/EMBC.2013.6610068

Retinal ganglion cells electrophysiology: The effect of cell morphology on impulse waveform

Matias I. Maturana, Raymond Wong, Shaun L. Cloherty, Michael R. Ibbotson, Alex E. Hadjinicolaou^*, David B. Grayden, Anthony N. Burkitt, Hamish Meffin, Brendan J. O'Brien, Tatiana Kameneva

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

There are 16 morphologically defined classes of rats retinal ganglion cells (RGCs). Using computer simulation of a realistic anatomically correct A1 mouse RGC, we investigate the effect of the cell's morphology on its impulse waveform, using the first-, and second-order time derivatives as well as the phase plot features. Using whole cell patch clamp recordings, we recorded the impulse waveform for each of the rat RGCs types. While we found some clear differences in many features of the impulse waveforms for A2 and B2 cells compared to other cell classes, many cell types did not show clear differences.

Original language	English
Title of host publication	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages	2583-2586
Number of pages	4
DOIs	https://doi.org/10.1109/EMBC.2013.6610068
Publication status	Published - 2013
Event	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan Duration: 3 Jul 2013 → 7 Jul 2013

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Conference

Conference	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Country/Territory	Japan
City	Osaka
Period	3/07/13 → 7/07/13

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10.1109/EMBC.2013.6610068

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Maturana, M. I., Wong, R., Cloherty, S. L., Ibbotson, M. R., Hadjinicolaou, A. E., Grayden, D. B., Burkitt, A. N., Meffin, H., O'Brien, B. J., & Kameneva, T. (2013). Retinal ganglion cells electrophysiology: The effect of cell morphology on impulse waveform. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 2583-2586). Article 6610068 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6610068

Maturana, Matias I. ; Wong, Raymond ; Cloherty, Shaun L. et al. / Retinal ganglion cells electrophysiology : The effect of cell morphology on impulse waveform. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. pp. 2583-2586 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

@inproceedings{fb360fa2955f471aac365004d9573028,

title = "Retinal ganglion cells electrophysiology: The effect of cell morphology on impulse waveform",

abstract = "There are 16 morphologically defined classes of rats retinal ganglion cells (RGCs). Using computer simulation of a realistic anatomically correct A1 mouse RGC, we investigate the effect of the cell's morphology on its impulse waveform, using the first-, and second-order time derivatives as well as the phase plot features. Using whole cell patch clamp recordings, we recorded the impulse waveform for each of the rat RGCs types. While we found some clear differences in many features of the impulse waveforms for A2 and B2 cells compared to other cell classes, many cell types did not show clear differences.",

author = "Maturana, {Matias I.} and Raymond Wong and Cloherty, {Shaun L.} and Ibbotson, {Michael R.} and Hadjinicolaou, {Alex E.} and Grayden, {David B.} and Burkitt, {Anthony N.} and Hamish Meffin and O'Brien, {Brendan J.} and Tatiana Kameneva",

year = "2013",

doi = "10.1109/EMBC.2013.6610068",

language = "English",

isbn = "9781457702167",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

pages = "2583--2586",

booktitle = "2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013",

note = "2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 ; Conference date: 03-07-2013 Through 07-07-2013",

}

Maturana, MI, Wong, R, Cloherty, SL, Ibbotson, MR, Hadjinicolaou, AE, Grayden, DB, Burkitt, AN, Meffin, H, O'Brien, BJ & Kameneva, T 2013, Retinal ganglion cells electrophysiology: The effect of cell morphology on impulse waveform. in 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013., 6610068, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 2583-2586, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 3/07/13. https://doi.org/10.1109/EMBC.2013.6610068

Retinal ganglion cells electrophysiology: The effect of cell morphology on impulse waveform. / Maturana, Matias I.; Wong, Raymond; Cloherty, Shaun L. et al.
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 2583-2586 6610068 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Retinal ganglion cells electrophysiology

T2 - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013

AU - Maturana, Matias I.

AU - Wong, Raymond

AU - Cloherty, Shaun L.

AU - Ibbotson, Michael R.

AU - Hadjinicolaou, Alex E.

AU - Grayden, David B.

AU - Burkitt, Anthony N.

AU - Meffin, Hamish

AU - O'Brien, Brendan J.

AU - Kameneva, Tatiana

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AB - There are 16 morphologically defined classes of rats retinal ganglion cells (RGCs). Using computer simulation of a realistic anatomically correct A1 mouse RGC, we investigate the effect of the cell's morphology on its impulse waveform, using the first-, and second-order time derivatives as well as the phase plot features. Using whole cell patch clamp recordings, we recorded the impulse waveform for each of the rat RGCs types. While we found some clear differences in many features of the impulse waveforms for A2 and B2 cells compared to other cell classes, many cell types did not show clear differences.

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Maturana MI, Wong R, Cloherty SL, Ibbotson MR, Hadjinicolaou AE, Grayden DB et al. Retinal ganglion cells electrophysiology: The effect of cell morphology on impulse waveform. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 2583-2586. 6610068. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2013.6610068

Retinal ganglion cells electrophysiology: The effect of cell morphology on impulse waveform

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