Reversible aqueous metathesis reactions for potential application in dynamic combinatorial chemistry

Luke Hunter, Glenn C. Condie, Margaret M. Harding

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Solutions of heterocycles having an allyl sulfide unit and simple alkenes in 50% t-BuOH/H2O undergo reversible olefin metathesis reactions with the second generation Hoveyda-Grubbs catalyst. The choice of functional groups is limited by competitive chelation of some heterocycles with the catalyst, and other stereoelectronic effects.

Original languageEnglish
Pages (from-to)5064-5067
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number38
DOIs
Publication statusPublished - 2010
Externally publishedYes

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