Abstract
Splenomegaly is a well-recognized complication in patients with common variable immunodeficiency (CVID), particularly those with an abnormal accumulation of mature CD21lo B cells in peripheral blood [1]. In CVID, splenomegaly is associated with hypersplenism, autoimmune cytopenias, and secondary lymphoma [2]. Patients with suspected lymphoma and refractory cytopenias may require splenectomy despite intensive treatment with steroids and rituximab, and this places them at increased risk of overwhelming post-splenectomy infections [3, 4]. We describe a patient with late-onset primary antibody deficiency, lymphoproliferative disease with generalized lymphadenopathy and massive plenomegaly, and progressive thrombocytopenia
Original language | English |
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Pages (from-to) | 159-162 |
Number of pages | 4 |
Journal | Journal of Clinical Immunology |
Volume | 38 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2018 |
Externally published | Yes |