Risk factors for infection with Campylobacter jejuni flaA genotypes

Leanne E. Unicomb; L. C. O'Reilly; M. D. Kirk; R. J. Stafford; H. V. Smith; N. G. Becker; M. S. Patel; G. L. Gilbert; Penny Adamson; Rosie Ashbolt; Kellie Cheung; Barry Combs; Craig Dalton; Steve Djordjevic; Robyn Doyle; John Ferguson; Lyn Gilbert; Rod Givney; David Gordon; Joy Gregory; Geo Hogg; Tim Inglis; Peter Jelfs; Karin Lalor; Jan Lanser; Lance Mickan; Rosa Rios; Minda Sarna; Hemant Sharma; Helen Smith; Leanne Unicomb; Mary Valcanis

doi:10.1017/S0950268807000246

Risk factors for infection with Campylobacter jejuni flaA genotypes

Leanne E. Unicomb^*, L. C. O'Reilly, M. D. Kirk, R. J. Stafford, H. V. Smith, N. G. Becker, M. S. Patel, G. L. Gilbert, Penny Adamson, Rosie Ashbolt, Kellie Cheung, Barry Combs, Craig Dalton, Steve Djordjevic, Robyn Doyle, John Ferguson, Lyn Gilbert, Rod Givney, David Gordon, Joy GregoryGeo Hogg, Tim Inglis, Peter Jelfs, Karin Lalor, Jan Lanser, Lance Mickan, Rosa Rios, Minda Sarna, Hemant Sharma, Helen Smith, Leanne Unicomb, Mary Valcanis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We aimed to explore Campylobacter genotype-specific risk factors in Australia. Isolates collected prospectively from cases recruited into a case-control study were genotyped using flaA restriction fragment-length polymorphism typing ( flaA genotyping). Exposure information for cases and controls was collected by telephone interview. Risk factors were examined for major flaA genotypes using logistic and multinomial regression. Five flaA genotypes accounted for 325 of 590 (55%) cases - flaA-6b (n=129), flaA-6 (n=70), flaA-10 (n=48), flaA-2 (n=43), flaA-131 (n=35). In Australia, infections due to flaA-10 and flaA-2 were found to be significantly associated with eating non-poultry meat (beef and ham, respectively) in both case-control and inter-genotype comparisons. All major genotypes apart from flaA-10 were associated with chicken consumption in the case-control comparisons. Based on several clinical criteria, infections due to flaA-2 were more severe than those due to other genotypes. Thus genotype analysis may reveal genotype-specific niches and differences in virulence and transmission routes.

Original language	English
Pages (from-to)	1480-1491
Number of pages	12
Journal	Epidemiology and Infection
Volume	136
Issue number	11
DOIs	https://doi.org/10.1017/S0950268807000246
Publication status	Published - 2008

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Unicomb, L. E., O'Reilly, L. C., Kirk, M. D., Stafford, R. J., Smith, H. V., Becker, N. G., Patel, M. S., Gilbert, G. L., Adamson, P., Ashbolt, R., Cheung, K., Combs, B., Dalton, C., Djordjevic, S., Doyle, R., Ferguson, J., Gilbert, L., Givney, R., Gordon, D., ... Valcanis, M. (2008). Risk factors for infection with Campylobacter jejuni flaA genotypes. Epidemiology and Infection, 136(11), 1480-1491. https://doi.org/10.1017/S0950268807000246

@article{3898dbd618784f8cb31c0aa9f3952733,

title = "Risk factors for infection with Campylobacter jejuni flaA genotypes",

abstract = "We aimed to explore Campylobacter genotype-specific risk factors in Australia. Isolates collected prospectively from cases recruited into a case-control study were genotyped using flaA restriction fragment-length polymorphism typing ( flaA genotyping). Exposure information for cases and controls was collected by telephone interview. Risk factors were examined for major flaA genotypes using logistic and multinomial regression. Five flaA genotypes accounted for 325 of 590 (55%) cases - flaA-6b (n=129), flaA-6 (n=70), flaA-10 (n=48), flaA-2 (n=43), flaA-131 (n=35). In Australia, infections due to flaA-10 and flaA-2 were found to be significantly associated with eating non-poultry meat (beef and ham, respectively) in both case-control and inter-genotype comparisons. All major genotypes apart from flaA-10 were associated with chicken consumption in the case-control comparisons. Based on several clinical criteria, infections due to flaA-2 were more severe than those due to other genotypes. Thus genotype analysis may reveal genotype-specific niches and differences in virulence and transmission routes.",

author = "Unicomb, {Leanne E.} and O'Reilly, {L. C.} and Kirk, {M. D.} and Stafford, {R. J.} and Smith, {H. V.} and Becker, {N. G.} and Patel, {M. S.} and Gilbert, {G. L.} and Penny Adamson and Rosie Ashbolt and Kellie Cheung and Barry Combs and Craig Dalton and Steve Djordjevic and Robyn Doyle and John Ferguson and Lyn Gilbert and Rod Givney and David Gordon and Joy Gregory and Geo Hogg and Tim Inglis and Peter Jelfs and Karin Lalor and Jan Lanser and Lance Mickan and Rosa Rios and Minda Sarna and Hemant Sharma and Helen Smith and Leanne Unicomb and Mary Valcanis",

year = "2008",

doi = "10.1017/S0950268807000246",

language = "English",

volume = "136",

pages = "1480--1491",

journal = "Epidemiology and Infection",

issn = "0950-2688",

publisher = "Cambridge University Press",

number = "11",

}

Unicomb, LE, O'Reilly, LC, Kirk, MD, Stafford, RJ, Smith, HV, Becker, NG, Patel, MS, Gilbert, GL, Adamson, P, Ashbolt, R, Cheung, K, Combs, B, Dalton, C, Djordjevic, S, Doyle, R, Ferguson, J, Gilbert, L, Givney, R, Gordon, D, Gregory, J, Hogg, G, Inglis, T, Jelfs, P, Lalor, K, Lanser, J, Mickan, L, Rios, R, Sarna, M, Sharma, H, Smith, H, Unicomb, L & Valcanis, M 2008, 'Risk factors for infection with Campylobacter jejuni flaA genotypes', Epidemiology and Infection, vol. 136, no. 11, pp. 1480-1491. https://doi.org/10.1017/S0950268807000246

TY - JOUR

T1 - Risk factors for infection with Campylobacter jejuni flaA genotypes

AU - Unicomb, Leanne E.

AU - O'Reilly, L. C.

AU - Kirk, M. D.

AU - Stafford, R. J.

AU - Smith, H. V.

AU - Becker, N. G.

AU - Patel, M. S.

AU - Gilbert, G. L.

AU - Adamson, Penny

AU - Ashbolt, Rosie

AU - Cheung, Kellie

AU - Combs, Barry

AU - Dalton, Craig

AU - Djordjevic, Steve

AU - Doyle, Robyn

AU - Ferguson, John

AU - Gilbert, Lyn

AU - Givney, Rod

AU - Gordon, David

AU - Gregory, Joy

AU - Hogg, Geo

AU - Inglis, Tim

AU - Jelfs, Peter

AU - Lalor, Karin

AU - Lanser, Jan

AU - Mickan, Lance

AU - Rios, Rosa

AU - Sarna, Minda

AU - Sharma, Hemant

AU - Smith, Helen

AU - Unicomb, Leanne

AU - Valcanis, Mary

PY - 2008

Y1 - 2008

N2 - We aimed to explore Campylobacter genotype-specific risk factors in Australia. Isolates collected prospectively from cases recruited into a case-control study were genotyped using flaA restriction fragment-length polymorphism typing ( flaA genotyping). Exposure information for cases and controls was collected by telephone interview. Risk factors were examined for major flaA genotypes using logistic and multinomial regression. Five flaA genotypes accounted for 325 of 590 (55%) cases - flaA-6b (n=129), flaA-6 (n=70), flaA-10 (n=48), flaA-2 (n=43), flaA-131 (n=35). In Australia, infections due to flaA-10 and flaA-2 were found to be significantly associated with eating non-poultry meat (beef and ham, respectively) in both case-control and inter-genotype comparisons. All major genotypes apart from flaA-10 were associated with chicken consumption in the case-control comparisons. Based on several clinical criteria, infections due to flaA-2 were more severe than those due to other genotypes. Thus genotype analysis may reveal genotype-specific niches and differences in virulence and transmission routes.

AB - We aimed to explore Campylobacter genotype-specific risk factors in Australia. Isolates collected prospectively from cases recruited into a case-control study were genotyped using flaA restriction fragment-length polymorphism typing ( flaA genotyping). Exposure information for cases and controls was collected by telephone interview. Risk factors were examined for major flaA genotypes using logistic and multinomial regression. Five flaA genotypes accounted for 325 of 590 (55%) cases - flaA-6b (n=129), flaA-6 (n=70), flaA-10 (n=48), flaA-2 (n=43), flaA-131 (n=35). In Australia, infections due to flaA-10 and flaA-2 were found to be significantly associated with eating non-poultry meat (beef and ham, respectively) in both case-control and inter-genotype comparisons. All major genotypes apart from flaA-10 were associated with chicken consumption in the case-control comparisons. Based on several clinical criteria, infections due to flaA-2 were more severe than those due to other genotypes. Thus genotype analysis may reveal genotype-specific niches and differences in virulence and transmission routes.

UR - http://www.scopus.com/inward/record.url?scp=54049097954&partnerID=8YFLogxK

U2 - 10.1017/S0950268807000246

DO - 10.1017/S0950268807000246

M3 - Article

SN - 0950-2688

VL - 136

SP - 1480

EP - 1491

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 11

ER -

Risk factors for infection with Campylobacter jejuni flaA genotypes

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