Role of T cell costimulation in anti-viral immunity

Edward M. Bertram; Wojciech Dawicki; Tania H. Watts

doi:10.1016/j.smim.2004.02.006

Role of T cell costimulation in anti-viral immunity

Edward M. Bertram, Wojciech Dawicki, Tania H. Watts^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

82 Citations (Scopus)

Abstract

Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.

Original language	English
Pages (from-to)	185-196
Number of pages	12
Journal	Seminars in Immunology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2004.02.006
Publication status	Published - Jun 2004

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10.1016/j.smim.2004.02.006

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title = "Role of T cell costimulation in anti-viral immunity",

abstract = "Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.",

keywords = "CD28 family, Costimulation, DLN, T cells, TIM, TK, TNF receptor associated factor, TNFR, TNFR family, TRAF, TRAF interacting motif, Viruses, draining lymph node, thymidine kinase, tumor necrosis factor receptor",

author = "Bertram, {Edward M.} and Wojciech Dawicki and Watts, {Tania H.}",

year = "2004",

month = jun,

doi = "10.1016/j.smim.2004.02.006",

language = "English",

volume = "16",

pages = "185--196",

journal = "Seminars in Immunology",

issn = "1044-5323",

publisher = "Academic Press",

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T1 - Role of T cell costimulation in anti-viral immunity

AU - Bertram, Edward M.

AU - Dawicki, Wojciech

AU - Watts, Tania H.

PY - 2004/6

Y1 - 2004/6

N2 - Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.

AB - Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.

KW - CD28 family

KW - Costimulation

KW - DLN

KW - T cells

KW - TIM

KW - TK

KW - TNF receptor associated factor

KW - TNFR

KW - TNFR family

KW - TRAF

KW - TRAF interacting motif

KW - Viruses

KW - draining lymph node

KW - thymidine kinase

KW - tumor necrosis factor receptor

UR - http://www.scopus.com/inward/record.url?scp=2342631978&partnerID=8YFLogxK

U2 - 10.1016/j.smim.2004.02.006

DO - 10.1016/j.smim.2004.02.006

M3 - Review article

SN - 1044-5323

VL - 16

SP - 185

EP - 196

JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 3

ER -

Role of T cell costimulation in anti-viral immunity

Abstract

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