Routine production of copper-64 using 11.7MeV protons

C. M. Jeffery; S. V. Smith; A. H. Asad; S. Chan; R. I. Price

doi:10.1063/1.4773946

Routine production of copper-64 using 11.7MeV protons

C. M. Jeffery^*, S. V. Smith, A. H. Asad, S. Chan, R. I. Price

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

16 Citations (Scopus)

Abstract

Reliable production of copper-64 (⁶⁴Cu) was achieved by irradiating enriched nickel-64 (⁶⁴Ni, >94.8%) in an IBA 18/9 cyclotron. Nickel-64 (19.1 ± 3.0 mg) was electroplated onto an Au disc (125μm × 15mm). Targets were irradiated with 11.7 MeV protons for 2 hours at 40μA. Copper isotopes (^60,61,62,64Cu) were separated from target nickel and cobalt isotopes (^55,57,61Co) using a single ion exchange column, eluted with varying concentration of low HCl alcohol solutions. The ⁶⁴Ni target material was recovered and reused. The ⁶⁴Cu production rate was 1.46±0.3MBq/μA.hr/mg ⁶⁴Ni(n=10) (with a maximum of 2.6GBq of ⁶⁴Cu isolated after 2hr irradiation at 40uA. Radionuclidic purity of the ⁶⁴Cu was 98.7 ± 1.6 % at end of separation. Cu content was < 6mg/L (n = 21). The specific activity of ⁶⁴Cu was determined by ICP-MS and by titration with Diamsar to be 28.9±13.0GBq/μmol[0.70±0.35Ci/ μmol]/(μA.hr/mg⁶⁴Ni)(n=10) and 13.1±12.0GBq/μmol[0. 35±0.32Ci/μmol]/(μA.hr/mg⁶⁴Ni)(n=9), respectively; which are in agreement, however, further work is required.

Original language	English
Title of host publication	14th International Workshop on Targetry and Target Chemistry
Pages	84-90
Number of pages	7
DOIs	https://doi.org/10.1063/1.4773946
Publication status	Published - 2012
Event	14th International Workshop on Targetry and Target Chemistry, WTTC 2012 - Playa del Carmen, Mexico Duration: 26 Aug 2012 → 29 Aug 2012

Publication series

Name	AIP Conference Proceedings
Volume	1509
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	14th International Workshop on Targetry and Target Chemistry, WTTC 2012
Country/Territory	Mexico
City	Playa del Carmen
Period	26/08/12 → 29/08/12

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10.1063/1.4773946

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@inproceedings{42d49d464dfa46138cc4e00e65053851,

title = "Routine production of copper-64 using 11.7MeV protons",

abstract = "Reliable production of copper-64 (64Cu) was achieved by irradiating enriched nickel-64 (64Ni, >94.8%) in an IBA 18/9 cyclotron. Nickel-64 (19.1 ± 3.0 mg) was electroplated onto an Au disc (125μm × 15mm). Targets were irradiated with 11.7 MeV protons for 2 hours at 40μA. Copper isotopes (60,61,62,64Cu) were separated from target nickel and cobalt isotopes (55,57,61Co) using a single ion exchange column, eluted with varying concentration of low HCl alcohol solutions. The 64Ni target material was recovered and reused. The 64Cu production rate was 1.46±0.3MBq/μA.hr/mg 64Ni(n=10) (with a maximum of 2.6GBq of 64Cu isolated after 2hr irradiation at 40uA. Radionuclidic purity of the 64Cu was 98.7 ± 1.6 % at end of separation. Cu content was < 6mg/L (n = 21). The specific activity of 64Cu was determined by ICP-MS and by titration with Diamsar to be 28.9±13.0GBq/μmol[0.70±0.35Ci/ μmol]/(μA.hr/mg64Ni)(n=10) and 13.1±12.0GBq/μmol[0. 35±0.32Ci/μmol]/(μA.hr/mg64Ni)(n=9), respectively; which are in agreement, however, further work is required.",

keywords = "Copper-64, PET, low energy cyclotron, nickel-64, specific activity",

author = "Jeffery, {C. M.} and Smith, {S. V.} and Asad, {A. H.} and S. Chan and Price, {R. I.}",

year = "2012",

doi = "10.1063/1.4773946",

language = "English",

isbn = "9780735411272",

series = "AIP Conference Proceedings",

pages = "84--90",

booktitle = "14th International Workshop on Targetry and Target Chemistry",

note = "14th International Workshop on Targetry and Target Chemistry, WTTC 2012 ; Conference date: 26-08-2012 Through 29-08-2012",

}

Jeffery, CM, Smith, SV, Asad, AH, Chan, S & Price, RI 2012, Routine production of copper-64 using 11.7MeV protons. in 14th International Workshop on Targetry and Target Chemistry. AIP Conference Proceedings, vol. 1509, pp. 84-90, 14th International Workshop on Targetry and Target Chemistry, WTTC 2012, Playa del Carmen, Mexico, 26/08/12. https://doi.org/10.1063/1.4773946

TY - GEN

T1 - Routine production of copper-64 using 11.7MeV protons

AU - Jeffery, C. M.

AU - Smith, S. V.

AU - Asad, A. H.

AU - Chan, S.

AU - Price, R. I.

PY - 2012

Y1 - 2012

N2 - Reliable production of copper-64 (64Cu) was achieved by irradiating enriched nickel-64 (64Ni, >94.8%) in an IBA 18/9 cyclotron. Nickel-64 (19.1 ± 3.0 mg) was electroplated onto an Au disc (125μm × 15mm). Targets were irradiated with 11.7 MeV protons for 2 hours at 40μA. Copper isotopes (60,61,62,64Cu) were separated from target nickel and cobalt isotopes (55,57,61Co) using a single ion exchange column, eluted with varying concentration of low HCl alcohol solutions. The 64Ni target material was recovered and reused. The 64Cu production rate was 1.46±0.3MBq/μA.hr/mg 64Ni(n=10) (with a maximum of 2.6GBq of 64Cu isolated after 2hr irradiation at 40uA. Radionuclidic purity of the 64Cu was 98.7 ± 1.6 % at end of separation. Cu content was < 6mg/L (n = 21). The specific activity of 64Cu was determined by ICP-MS and by titration with Diamsar to be 28.9±13.0GBq/μmol[0.70±0.35Ci/ μmol]/(μA.hr/mg64Ni)(n=10) and 13.1±12.0GBq/μmol[0. 35±0.32Ci/μmol]/(μA.hr/mg64Ni)(n=9), respectively; which are in agreement, however, further work is required.

AB - Reliable production of copper-64 (64Cu) was achieved by irradiating enriched nickel-64 (64Ni, >94.8%) in an IBA 18/9 cyclotron. Nickel-64 (19.1 ± 3.0 mg) was electroplated onto an Au disc (125μm × 15mm). Targets were irradiated with 11.7 MeV protons for 2 hours at 40μA. Copper isotopes (60,61,62,64Cu) were separated from target nickel and cobalt isotopes (55,57,61Co) using a single ion exchange column, eluted with varying concentration of low HCl alcohol solutions. The 64Ni target material was recovered and reused. The 64Cu production rate was 1.46±0.3MBq/μA.hr/mg 64Ni(n=10) (with a maximum of 2.6GBq of 64Cu isolated after 2hr irradiation at 40uA. Radionuclidic purity of the 64Cu was 98.7 ± 1.6 % at end of separation. Cu content was < 6mg/L (n = 21). The specific activity of 64Cu was determined by ICP-MS and by titration with Diamsar to be 28.9±13.0GBq/μmol[0.70±0.35Ci/ μmol]/(μA.hr/mg64Ni)(n=10) and 13.1±12.0GBq/μmol[0. 35±0.32Ci/μmol]/(μA.hr/mg64Ni)(n=9), respectively; which are in agreement, however, further work is required.

KW - Copper-64

KW - PET

KW - low energy cyclotron

KW - nickel-64

KW - specific activity

UR - http://www.scopus.com/inward/record.url?scp=84874379721&partnerID=8YFLogxK

U2 - 10.1063/1.4773946

DO - 10.1063/1.4773946

M3 - Conference contribution

SN - 9780735411272

T3 - AIP Conference Proceedings

SP - 84

EP - 90

BT - 14th International Workshop on Targetry and Target Chemistry

T2 - 14th International Workshop on Targetry and Target Chemistry, WTTC 2012

Y2 - 26 August 2012 through 29 August 2012

ER -

Routine production of copper-64 using 11.7MeV protons

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