Safe and effective: Anti-tumour necrosis factor therapy use in pregnant patients with Crohn disease and ulcerative colitis

C. J. Kiely; K. Subramaniam; J. Platten; P. Pavli

doi:10.1111/imj.13057

Safe and effective: Anti-tumour necrosis factor therapy use in pregnant patients with Crohn disease and ulcerative colitis

C. J. Kiely^*
, K. Subramaniam
, J. Platten
, P. Pavli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Biological therapy, particularly the anti-tumour necrosis factor (TNF) antibodies, infliximab and adalimumab, are used for the maintenance of remission for patients with inflammatory bowel diseases (IBD). We present 21 pregnancies in IBD patients exposed to anti-TNF agents between 2007 and 2014. Our study demonstrates that anti-TNF therapy is safe and effective in pregnancy. Rates of foetal complications are similar to IBD cohorts from the pre anti-TNF era.

Original language	English
Pages (from-to)	616-619
Number of pages	4
Journal	Internal Medicine Journal
Volume	46
Issue number	5
DOIs	https://doi.org/10.1111/imj.13057
Publication status	Published - 1 May 2016

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10.1111/imj.13057

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title = "Safe and effective: Anti-tumour necrosis factor therapy use in pregnant patients with Crohn disease and ulcerative colitis",

abstract = "Biological therapy, particularly the anti-tumour necrosis factor (TNF) antibodies, infliximab and adalimumab, are used for the maintenance of remission for patients with inflammatory bowel diseases (IBD). We present 21 pregnancies in IBD patients exposed to anti-TNF agents between 2007 and 2014. Our study demonstrates that anti-TNF therapy is safe and effective in pregnancy. Rates of foetal complications are similar to IBD cohorts from the pre anti-TNF era.",

keywords = "Crohn disease, Inflammatory bowel disease, Pregnancy, Tumour necrosis factor-alpha, Ulcerative colitis",

author = "Kiely, \{C. J.\} and K. Subramaniam and J. Platten and P. Pavli",

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AU - Kiely, C. J.

AU - Subramaniam, K.

AU - Platten, J.

AU - Pavli, P.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Biological therapy, particularly the anti-tumour necrosis factor (TNF) antibodies, infliximab and adalimumab, are used for the maintenance of remission for patients with inflammatory bowel diseases (IBD). We present 21 pregnancies in IBD patients exposed to anti-TNF agents between 2007 and 2014. Our study demonstrates that anti-TNF therapy is safe and effective in pregnancy. Rates of foetal complications are similar to IBD cohorts from the pre anti-TNF era.

AB - Biological therapy, particularly the anti-tumour necrosis factor (TNF) antibodies, infliximab and adalimumab, are used for the maintenance of remission for patients with inflammatory bowel diseases (IBD). We present 21 pregnancies in IBD patients exposed to anti-TNF agents between 2007 and 2014. Our study demonstrates that anti-TNF therapy is safe and effective in pregnancy. Rates of foetal complications are similar to IBD cohorts from the pre anti-TNF era.

KW - Crohn disease

KW - Inflammatory bowel disease

KW - Pregnancy

KW - Tumour necrosis factor-alpha

KW - Ulcerative colitis

UR - https://www.scopus.com/pages/publications/84969286786

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JF - Internal Medicine Journal

IS - 5

ER -

Safe and effective: Anti-tumour necrosis factor therapy use in pregnant patients with Crohn disease and ulcerative colitis

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