Safety issues in adaptive control systems for automatic administration of vasoactive drugs

Nicolò Malagutti*, Arvin Dehghani, Rodney A. Kennedy

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    4 Citations (Scopus)


    Automatic administration of drugs to control cardiovascular function during and after surgery has received considerable attention. Although the potential benefits associated with such a technology remain unquestioned, the several adaptive control strategies proposed thus far have had very limited success in practice. In developing robust adaptive control methodologies for drug dosing in cardiovascular applications, we have analysed a well-known multiple-model adaptive control strategy for blood pressure control. The results reveal that no guarantee of protection against actually inserting a destabilising controller into the closed-loop is given and one cannot even put a global upper bound on the time during which the destabilising controller is attached.We advocate caution towards issues which in the past may have been either disregarded or not subjected to a systematic analysis as instability could be fatal in the context of a clinical application.

    Original languageEnglish
    Title of host publicationProceedings of the 18th IFAC World Congress
    PublisherIFAC Secretariat
    Number of pages6
    Edition1 PART 1
    ISBN (Print)9783902661937
    Publication statusPublished - 2011

    Publication series

    NameIFAC Proceedings Volumes (IFAC-PapersOnline)
    Number1 PART 1
    ISSN (Print)1474-6670


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