SARS-CoV-2 vaccines: Inactivation by gamma irradiation for T and B cell immunity

Arno Mullbacher; Julian Pardo; Yoichi Furuya

doi:10.3390/pathogens9110928

SARS-CoV-2 vaccines: Inactivation by gamma irradiation for T and B cell immunity

Arno Mullbacher, Julian Pardo, Yoichi Furuya^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Despite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-term protection against COVID-19. Further, we propose that gamma-ray irradiation, which is a previously tested inactivation method, may be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity involving both B and T cells.

Original language	English
Article number	928
Pages (from-to)	1-5
Number of pages	5
Journal	Pathogens
Volume	9
Issue number	11
DOIs	https://doi.org/10.3390/pathogens9110928
Publication status	Published - Nov 2020

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abstract = "Despite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-term protection against COVID-19. Further, we propose that gamma-ray irradiation, which is a previously tested inactivation method, may be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity involving both B and T cells.",

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SARS-CoV-2 vaccines: Inactivation by gamma irradiation for T and B cell immunity

Abstract

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