TY - JOUR
T1 - Scabrosin esters and derivatives
T2 - Chemical derivatization studies and biological evaluation
AU - Chai, Christina L.L.
AU - Elix, John A.
AU - Huleatt, Paul B.
AU - Waring, Paul
PY - 2004/11/15
Y1 - 2004/11/15
N2 - Several derivatives of the natural scabrosin esters were synthesized in order to elucidate the structural features present, which are responsible for the biological activities. The studies demonstrate that full anti-proliferative activities of the scabrosin esters, both the carboskeleton core as well as the ability to form the dithiol and/or the disulfide linkage of the epidithiopiperazine-2,5-dione are required. The presence of the epoxide rings on the scabrosin esters do not contribute to the observed biological activities.
AB - Several derivatives of the natural scabrosin esters were synthesized in order to elucidate the structural features present, which are responsible for the biological activities. The studies demonstrate that full anti-proliferative activities of the scabrosin esters, both the carboskeleton core as well as the ability to form the dithiol and/or the disulfide linkage of the epidithiopiperazine-2,5-dione are required. The presence of the epoxide rings on the scabrosin esters do not contribute to the observed biological activities.
KW - Anti-proliferative agents
KW - Anti-tumour compounds
KW - Natural products
KW - Polycyclic heterocyclic compounds
UR - http://www.scopus.com/inward/record.url?scp=6344242849&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2004.08.015
DO - 10.1016/j.bmc.2004.08.015
M3 - Article
SN - 0968-0896
VL - 12
SP - 5991
EP - 5995
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 22
ER -