Schistosomiasis in the People's Republic of China - Down but not out

Catherine A. Gordon; Gail M. Williams; Darren J. Gray; Archie C.A. Clements; Xiao Nong Zhou; Yuesheng Li; Jürg Utzinger; Johanna Kurscheid; Simon Forsyth; Kefyalew Addis Alene; Jie Zhou; Zhaojun Li; Guangpin Li; Dandan Lin; Zhihong Lou; Shengming Li; Jun Ge; Jing Xu; Xinling Yu; Fei Hu; Shuying Xie; Jie Chen; Tao Shi; Chong Li; Huajun Zheng; Donald P. McManus

doi:10.1017/S0031182021001724

Schistosomiasis in the People's Republic of China - Down but not out

Catherine A. Gordon^*, Gail M. Williams, Darren J. Gray, Archie C.A. Clements, Xiao Nong Zhou, Yuesheng Li, Jürg Utzinger, Johanna Kurscheid, Simon Forsyth, Kefyalew Addis Alene, Jie Zhou, Zhaojun Li, Guangpin Li, Dandan Lin, Zhihong Lou, Shengming Li, Jun Ge, Jing Xu, Xinling Yu, Fei HuShuying Xie, Jie Chen, Tao Shi, Chong Li, Huajun Zheng, Donald P. McManus^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Schistosomiasis has been subjected to extensive control efforts in the People's Republic of China (China) which aims to eliminate the disease by 2030. We describe baseline results of a longitudinal cohort study undertaken in the Dongting and Poyang lakes areas of central China designed to determine the prevalence of Schistosoma japonicum in humans, animals (goats and bovines) and Oncomelania snails utilizing molecular diagnostics procedures. Data from the Chinese National Schistosomiasis Control Programme (CNSCP) were compared with the molecular results obtained. Sixteen villages from Hunan and Jiangxi provinces were surveyed; animals were only found in Hunan. The prevalence of schistosomiasis in humans was 1.8% in Jiangxi and 8.0% in Hunan determined by real-time polymerase chain reaction (PCR), while 18.3% of animals were positive by digital droplet PCR. The CNSCP data indicated that all villages harboured S. japonicum-infected individuals, detected serologically by indirect haemagglutination assay (IHA), but very few, if any, of these were subsequently positive by Kato-Katz (KK). Based on the outcome of the IHA and KK results, the CNSCP incorporates targeted human praziquantel chemotherapy but this approach can miss some infections as evidenced by the results reported here. Sensitive molecular diagnostics can play a key role in the elimination of schistosomiasis in China and inform control measures allowing for a more systematic approach to treatment.

Original language	English
Pages (from-to)	218-233
Number of pages	16
Journal	Parasitology
Volume	149
Issue number	2
DOIs	https://doi.org/10.1017/S0031182021001724
Publication status	Published - 3 Feb 2022

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Gordon, C. A., Williams, G. M., Gray, D. J., Clements, A. C. A., Zhou, X. N., Li, Y., Utzinger, J., Kurscheid, J., Forsyth, S., Alene, K. A., Zhou, J., Li, Z., Li, G., Lin, D., Lou, Z., Li, S., Ge, J., Xu, J., Yu, X., ... McManus, D. P. (2022). Schistosomiasis in the People's Republic of China - Down but not out. Parasitology, 149(2), 218-233. https://doi.org/10.1017/S0031182021001724

@article{029a5523ac8840dab10881da3b149429,

title = "Schistosomiasis in the People's Republic of China - Down but not out",

abstract = "Schistosomiasis has been subjected to extensive control efforts in the People's Republic of China (China) which aims to eliminate the disease by 2030. We describe baseline results of a longitudinal cohort study undertaken in the Dongting and Poyang lakes areas of central China designed to determine the prevalence of Schistosoma japonicum in humans, animals (goats and bovines) and Oncomelania snails utilizing molecular diagnostics procedures. Data from the Chinese National Schistosomiasis Control Programme (CNSCP) were compared with the molecular results obtained. Sixteen villages from Hunan and Jiangxi provinces were surveyed; animals were only found in Hunan. The prevalence of schistosomiasis in humans was 1.8% in Jiangxi and 8.0% in Hunan determined by real-time polymerase chain reaction (PCR), while 18.3% of animals were positive by digital droplet PCR. The CNSCP data indicated that all villages harboured S. japonicum-infected individuals, detected serologically by indirect haemagglutination assay (IHA), but very few, if any, of these were subsequently positive by Kato-Katz (KK). Based on the outcome of the IHA and KK results, the CNSCP incorporates targeted human praziquantel chemotherapy but this approach can miss some infections as evidenced by the results reported here. Sensitive molecular diagnostics can play a key role in the elimination of schistosomiasis in China and inform control measures allowing for a more systematic approach to treatment.",

keywords = "Chinese National Schistosomiasis Control Programme, Dongting lake, Hunan province, Jiangxi province, Kato-Katz, LAMP, People's Republic of China, Poyang lake, Real-time PCR (qPCR), Schistosoma japonicum, Schistosomiasis, digital droplet PCR (ddPCR)",

author = "Gordon, {Catherine A.} and Williams, {Gail M.} and Gray, {Darren J.} and Clements, {Archie C.A.} and Zhou, {Xiao Nong} and Yuesheng Li and J{\"u}rg Utzinger and Johanna Kurscheid and Simon Forsyth and Alene, {Kefyalew Addis} and Jie Zhou and Zhaojun Li and Guangpin Li and Dandan Lin and Zhihong Lou and Shengming Li and Jun Ge and Jing Xu and Xinling Yu and Fei Hu and Shuying Xie and Jie Chen and Tao Shi and Chong Li and Huajun Zheng and McManus, {Donald P.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s).",

year = "2022",

month = feb,

day = "3",

doi = "10.1017/S0031182021001724",

language = "English",

volume = "149",

pages = "218--233",

journal = "Parasitology",

issn = "0031-1820",

publisher = "Cambridge University Press",

number = "2",

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Gordon, CA, Williams, GM, Gray, DJ, Clements, ACA, Zhou, XN, Li, Y, Utzinger, J, Kurscheid, J, Forsyth, S, Alene, KA, Zhou, J, Li, Z, Li, G, Lin, D, Lou, Z, Li, S, Ge, J, Xu, J, Yu, X, Hu, F, Xie, S, Chen, J, Shi, T, Li, C, Zheng, H & McManus, DP 2022, 'Schistosomiasis in the People's Republic of China - Down but not out', Parasitology, vol. 149, no. 2, pp. 218-233. https://doi.org/10.1017/S0031182021001724

TY - JOUR

T1 - Schistosomiasis in the People's Republic of China - Down but not out

AU - Gordon, Catherine A.

AU - Williams, Gail M.

AU - Gray, Darren J.

AU - Clements, Archie C.A.

AU - Zhou, Xiao Nong

AU - Li, Yuesheng

AU - Utzinger, Jürg

AU - Kurscheid, Johanna

AU - Forsyth, Simon

AU - Alene, Kefyalew Addis

AU - Zhou, Jie

AU - Li, Zhaojun

AU - Li, Guangpin

AU - Lin, Dandan

AU - Lou, Zhihong

AU - Li, Shengming

AU - Ge, Jun

AU - Xu, Jing

AU - Yu, Xinling

AU - Hu, Fei

AU - Xie, Shuying

AU - Chen, Jie

AU - Shi, Tao

AU - Li, Chong

AU - Zheng, Huajun

AU - McManus, Donald P.

PY - 2022/2/3

Y1 - 2022/2/3

N2 - Schistosomiasis has been subjected to extensive control efforts in the People's Republic of China (China) which aims to eliminate the disease by 2030. We describe baseline results of a longitudinal cohort study undertaken in the Dongting and Poyang lakes areas of central China designed to determine the prevalence of Schistosoma japonicum in humans, animals (goats and bovines) and Oncomelania snails utilizing molecular diagnostics procedures. Data from the Chinese National Schistosomiasis Control Programme (CNSCP) were compared with the molecular results obtained. Sixteen villages from Hunan and Jiangxi provinces were surveyed; animals were only found in Hunan. The prevalence of schistosomiasis in humans was 1.8% in Jiangxi and 8.0% in Hunan determined by real-time polymerase chain reaction (PCR), while 18.3% of animals were positive by digital droplet PCR. The CNSCP data indicated that all villages harboured S. japonicum-infected individuals, detected serologically by indirect haemagglutination assay (IHA), but very few, if any, of these were subsequently positive by Kato-Katz (KK). Based on the outcome of the IHA and KK results, the CNSCP incorporates targeted human praziquantel chemotherapy but this approach can miss some infections as evidenced by the results reported here. Sensitive molecular diagnostics can play a key role in the elimination of schistosomiasis in China and inform control measures allowing for a more systematic approach to treatment.

AB - Schistosomiasis has been subjected to extensive control efforts in the People's Republic of China (China) which aims to eliminate the disease by 2030. We describe baseline results of a longitudinal cohort study undertaken in the Dongting and Poyang lakes areas of central China designed to determine the prevalence of Schistosoma japonicum in humans, animals (goats and bovines) and Oncomelania snails utilizing molecular diagnostics procedures. Data from the Chinese National Schistosomiasis Control Programme (CNSCP) were compared with the molecular results obtained. Sixteen villages from Hunan and Jiangxi provinces were surveyed; animals were only found in Hunan. The prevalence of schistosomiasis in humans was 1.8% in Jiangxi and 8.0% in Hunan determined by real-time polymerase chain reaction (PCR), while 18.3% of animals were positive by digital droplet PCR. The CNSCP data indicated that all villages harboured S. japonicum-infected individuals, detected serologically by indirect haemagglutination assay (IHA), but very few, if any, of these were subsequently positive by Kato-Katz (KK). Based on the outcome of the IHA and KK results, the CNSCP incorporates targeted human praziquantel chemotherapy but this approach can miss some infections as evidenced by the results reported here. Sensitive molecular diagnostics can play a key role in the elimination of schistosomiasis in China and inform control measures allowing for a more systematic approach to treatment.

KW - Chinese National Schistosomiasis Control Programme

KW - Dongting lake

KW - Hunan province

KW - Jiangxi province

KW - Kato-Katz

KW - LAMP

KW - People's Republic of China

KW - Poyang lake

KW - Real-time PCR (qPCR)

KW - Schistosoma japonicum

KW - Schistosomiasis

KW - digital droplet PCR (ddPCR)

UR - http://www.scopus.com/inward/record.url?scp=85119201857&partnerID=8YFLogxK

U2 - 10.1017/S0031182021001724

DO - 10.1017/S0031182021001724

M3 - Article

SN - 0031-1820

VL - 149

SP - 218

EP - 233

JO - Parasitology

JF - Parasitology

IS - 2

ER -

Schistosomiasis in the People's Republic of China - Down but not out

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