Self-adjuvanting multicomponent cancer vaccine candidates combining per-glycosylated muc1 glycopeptides and the toll-like receptor 2 agonist pam₃CysSer

More sugar with your "T": The title candidates comprising per-glycosylated MUC1 peptides, a T-cell helper peptide, and an immunoadjuvant were assembled in high yields using iterative pentafluorophenyl ester-mediated fragment condensations. Following immunological evaluation, a tricomponent vaccine bearing clustered glycosylation with the T-antigen was identified (see structure) which elicited high IgG antibody titers in murine models without an external adjuvant.