Severe pertussis in infants: Estimated impact of first vaccine dose at 6 versus 8 weeks in Australia

Alice Ruth Foxwell; Peter McIntyre; Helen Quinn; Katrina Roper; Mark S. Clements

doi:10.1097/INF.0b013e3181f43906

Severe pertussis in infants: Estimated impact of first vaccine dose at 6 versus 8 weeks in Australia

Alice Ruth Foxwell, Peter McIntyre, Helen Quinn, Katrina Roper, Mark S. Clements

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We estimated the potential benefits of advancing the first dose of pertussis vaccine for infants from 8 to 6 weeks of age, using Australian national disease databases. Infants had notification rates 3-fold greater than the general population and accounted for 52% of recorded hospitalizations. Infants 1 and 2 months of age had notification rates 3.5 times (95% CI: 2.7-4.5) higher than infants 3 to 11 months of age. Estimation of acceleration of the vaccine to 6 weeks of age reduced average notifications, hospitalizations, and hospital bed-days by 8%, 9%, and 12%, respectively, with larger reductions in an epidemic year.

Original language	English
Pages (from-to)	161-163
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	30
Issue number	2
DOIs	https://doi.org/10.1097/INF.0b013e3181f43906
Publication status	Published - Feb 2011

Access to Document

10.1097/INF.0b013e3181f43906

Cite this

@article{922faf675f5b4f75bb851a6ac7fe1e22,

title = "Severe pertussis in infants: Estimated impact of first vaccine dose at 6 versus 8 weeks in Australia",

abstract = "We estimated the potential benefits of advancing the first dose of pertussis vaccine for infants from 8 to 6 weeks of age, using Australian national disease databases. Infants had notification rates 3-fold greater than the general population and accounted for 52% of recorded hospitalizations. Infants 1 and 2 months of age had notification rates 3.5 times (95% CI: 2.7-4.5) higher than infants 3 to 11 months of age. Estimation of acceleration of the vaccine to 6 weeks of age reduced average notifications, hospitalizations, and hospital bed-days by 8%, 9%, and 12%, respectively, with larger reductions in an epidemic year.",

keywords = "immunization, pertussis, vaccine, whooping cough",

author = "Foxwell, {Alice Ruth} and Peter McIntyre and Helen Quinn and Katrina Roper and Clements, {Mark S.}",

year = "2011",

month = feb,

doi = "10.1097/INF.0b013e3181f43906",

language = "English",

volume = "30",

pages = "161--163",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "2",

}

TY - JOUR

T1 - Severe pertussis in infants

T2 - Estimated impact of first vaccine dose at 6 versus 8 weeks in Australia

AU - Foxwell, Alice Ruth

AU - McIntyre, Peter

AU - Quinn, Helen

AU - Roper, Katrina

AU - Clements, Mark S.

PY - 2011/2

Y1 - 2011/2

N2 - We estimated the potential benefits of advancing the first dose of pertussis vaccine for infants from 8 to 6 weeks of age, using Australian national disease databases. Infants had notification rates 3-fold greater than the general population and accounted for 52% of recorded hospitalizations. Infants 1 and 2 months of age had notification rates 3.5 times (95% CI: 2.7-4.5) higher than infants 3 to 11 months of age. Estimation of acceleration of the vaccine to 6 weeks of age reduced average notifications, hospitalizations, and hospital bed-days by 8%, 9%, and 12%, respectively, with larger reductions in an epidemic year.

AB - We estimated the potential benefits of advancing the first dose of pertussis vaccine for infants from 8 to 6 weeks of age, using Australian national disease databases. Infants had notification rates 3-fold greater than the general population and accounted for 52% of recorded hospitalizations. Infants 1 and 2 months of age had notification rates 3.5 times (95% CI: 2.7-4.5) higher than infants 3 to 11 months of age. Estimation of acceleration of the vaccine to 6 weeks of age reduced average notifications, hospitalizations, and hospital bed-days by 8%, 9%, and 12%, respectively, with larger reductions in an epidemic year.

KW - immunization

KW - pertussis

KW - vaccine

KW - whooping cough

UR - http://www.scopus.com/inward/record.url?scp=79551582040&partnerID=8YFLogxK

U2 - 10.1097/INF.0b013e3181f43906

DO - 10.1097/INF.0b013e3181f43906

M3 - Article

SN - 0891-3668

VL - 30

SP - 161

EP - 163

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 2

ER -

Severe pertussis in infants: Estimated impact of first vaccine dose at 6 versus 8 weeks in Australia

Abstract

Access to Document

Other files and links

Fingerprint

Cite this