Sex chromosome specialization and degeneration in mammals

Jennifer A.Marshall Graves

doi:10.1016/j.cell.2006.02.024

Sex chromosome specialization and degeneration in mammals

Jennifer A.Marshall Graves^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

459 Citations (Scopus)

Abstract

Sex chromosomes - particularly the human Y - have been a source of fascination for decades because of their unique transmission patterns and their peculiar cytology. The outpouring of genomic data confirms that their atypical structure and gene composition break the rules of genome organization, function, and evolution. The X has been shaped by dosage differences to have a biased gene content and to be subject to inactivation in females. The Y chromosome seems to be a product of a perverse evolutionary process that does not select the fittest Y, which may cause its degradation and ultimate extinction.

Original language	English
Pages (from-to)	901-914
Number of pages	14
Journal	Cell
Volume	124
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2006.02.024
Publication status	Published - 10 Mar 2006

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AB - Sex chromosomes - particularly the human Y - have been a source of fascination for decades because of their unique transmission patterns and their peculiar cytology. The outpouring of genomic data confirms that their atypical structure and gene composition break the rules of genome organization, function, and evolution. The X has been shaped by dosage differences to have a biased gene content and to be subject to inactivation in females. The Y chromosome seems to be a product of a perverse evolutionary process that does not select the fittest Y, which may cause its degradation and ultimate extinction.

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Sex chromosome specialization and degeneration in mammals

Abstract

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