TY - JOUR
T1 - Shape abnormalities of the caudate nucleus correlate with poorer gait and balance
T2 - Results from a subset of the ladis study
AU - Macfarlane, Matthew D.
AU - Looi, Jeffrey C.L.
AU - Walterfang, Mark
AU - Spulber, Gabriela
AU - Velakoulis, Dennis
AU - Styner, Martin
AU - Crisby, Milita
AU - Örndahl, Eva
AU - Erkinjuntti, Timo
AU - Waldemar, Gunhild
AU - Garde, Ellen
AU - Hennerici, Michael G.
AU - Bäzner, Hansjörg
AU - Blahak, Christian
AU - Wallin, Anders
AU - Wahlund, Lars Olof
AU - Pohjasvaara, Tarja
AU - Pihanen, Pia
AU - Ylikoski, Raija
AU - Jokinen, Hanna
AU - Somerkoski, Meija Marjut
AU - Mäntylä, Riitta
AU - Salonen, Oili
AU - Fazekas, Franz
AU - Schmidt, Reinhold
AU - Ropele, Stefan
AU - Rous, Brigitte
AU - Petrovic, Katja
AU - Garmehi, Ulrike
AU - Seewann, Alexandra
AU - Ferro, José M.
AU - Verdelho, Ana
AU - Madureira, Sofia
AU - Moleiro, Carla
AU - Scheltens, Philip
AU - Van Straaten, Ilse
AU - Barkhof, Frederik
AU - Gouw, Alida
AU - Van Der Flier, Wiesje
AU - Jonsson, Michael
AU - Lind, Karin
AU - Nordlund, Arto
AU - Rolstad, Sindre
AU - Isblad, Ingela
AU - Pettersson, Anna
AU - Amberla, Kaarina
AU - Chabriat, Hugues
AU - Hernandez, Karen
AU - Kurtz, Annie
AU - Herveacute, Dominique
N1 - Publisher Copyright:
© 2015 American Association for Geriatric Psychiatry.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objective Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in frontostriatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter hyperintensities (WMHs) on magnetic resonance imaging has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction. Methods Magnetic resonance imaging scans and clinical gait/balance data (scores from the Short Physical Performance Battery [SPPB]) were sourced from 66 subjects in the previously published LADIS trial, performed in nondisabled individuals older than age 65 years with WMHs at study entry. Data were obtained at study entry and at 3-year follow-up. Caudate nuclei and putamina were manually traced using a previously published method and volumes calculated. The relationships between volume and physical performance on the SPPB were investigated with shape analysis using the spherical harmonic shape description toolkit. Results There was no correlation between the severity of WMHs and striatal volumes. Caudate nuclei volume correlated with performance on the SPPB at baseline but not at follow-up, with subsequent shape analysis showing left caudate changes occurred in areas corresponding to inputs of the dorsolateral prefrontal, premotor, and motor cortex. There was no correlation between putamen volumes and performance on the SPPB. Conclusion Disruption in frontostriatal circuits may play a role in mediating poorer physical performance in individuals with WMHs. Striatal volume and shape changes may be suitable biomarkers for functional changes in this population.
AB - Objective Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in frontostriatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter hyperintensities (WMHs) on magnetic resonance imaging has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction. Methods Magnetic resonance imaging scans and clinical gait/balance data (scores from the Short Physical Performance Battery [SPPB]) were sourced from 66 subjects in the previously published LADIS trial, performed in nondisabled individuals older than age 65 years with WMHs at study entry. Data were obtained at study entry and at 3-year follow-up. Caudate nuclei and putamina were manually traced using a previously published method and volumes calculated. The relationships between volume and physical performance on the SPPB were investigated with shape analysis using the spherical harmonic shape description toolkit. Results There was no correlation between the severity of WMHs and striatal volumes. Caudate nuclei volume correlated with performance on the SPPB at baseline but not at follow-up, with subsequent shape analysis showing left caudate changes occurred in areas corresponding to inputs of the dorsolateral prefrontal, premotor, and motor cortex. There was no correlation between putamen volumes and performance on the SPPB. Conclusion Disruption in frontostriatal circuits may play a role in mediating poorer physical performance in individuals with WMHs. Striatal volume and shape changes may be suitable biomarkers for functional changes in this population.
KW - MRI
KW - Striatum
KW - caudate nucleus
KW - gait
KW - white matter disease
UR - http://www.scopus.com/inward/record.url?scp=84928026764&partnerID=8YFLogxK
U2 - 10.1016/j.jagp.2013.04.011
DO - 10.1016/j.jagp.2013.04.011
M3 - Article
SN - 1064-7481
VL - 23
SP - 59-71.e1
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 1
ER -