Shear-Thinning and Designable Responsive Supramolecular DNA Hydrogels Based on Chemically Branched DNA

Bo Yang; Zhihan Zhao; Yufan Pan; Jiayin Xie; Bini Zhou; Yujie Li; Yuanchen Dong; Dongsheng Liu

doi:10.1021/acsami.1c15494

Shear-Thinning and Designable Responsive Supramolecular DNA Hydrogels Based on Chemically Branched DNA

Bo Yang, Zhihan Zhao, Yufan Pan, Jiayin Xie, Bini Zhou, Yujie Li, Yuanchen Dong, Dongsheng Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

A novel supramolecular DNA hydrogel system was designed based on a directly synthesized chemically branched DNA. For the hydrogel formation, a self-dimer DNA with two sticky ends was designed as the linker to induce the gelation of B-Y. By programing the linker sequence, thermal and metal-ion responsiveness could be introduced into this hydrogel system. This supramolecular DNA hydrogel shows shear-thinning, designable responsiveness, and good biocompatibility, which will simplify the hydrogel composition and preparation process of the supramolecular DNA hydrogel and accelerate its biomedical applications.

Original language	English
Pages (from-to)	48414-48422
Number of pages	9
Journal	ACS Applied Materials and Interfaces
Volume	13
Issue number	41
Early online date	11 Oct 2021
DOIs	https://doi.org/10.1021/acsami.1c15494
Publication status	Published - 20 Oct 2021
Externally published	Yes

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abstract = "A novel supramolecular DNA hydrogel system was designed based on a directly synthesized chemically branched DNA. For the hydrogel formation, a self-dimer DNA with two sticky ends was designed as the linker to induce the gelation of B-Y. By programing the linker sequence, thermal and metal-ion responsiveness could be introduced into this hydrogel system. This supramolecular DNA hydrogel shows shear-thinning, designable responsiveness, and good biocompatibility, which will simplify the hydrogel composition and preparation process of the supramolecular DNA hydrogel and accelerate its biomedical applications.",

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AU - Yang, Bo

AU - Zhao, Zhihan

AU - Pan, Yufan

AU - Xie, Jiayin

AU - Zhou, Bini

AU - Li, Yujie

AU - Dong, Yuanchen

AU - Liu, Dongsheng

PY - 2021/10/20

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AB - A novel supramolecular DNA hydrogel system was designed based on a directly synthesized chemically branched DNA. For the hydrogel formation, a self-dimer DNA with two sticky ends was designed as the linker to induce the gelation of B-Y. By programing the linker sequence, thermal and metal-ion responsiveness could be introduced into this hydrogel system. This supramolecular DNA hydrogel shows shear-thinning, designable responsiveness, and good biocompatibility, which will simplify the hydrogel composition and preparation process of the supramolecular DNA hydrogel and accelerate its biomedical applications.

KW - 3D cell culture

KW - branched DNA

KW - shear-thinning property

KW - stimuli-responsive material

KW - supramolecular DNA hydrogel

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Shear-Thinning and Designable Responsive Supramolecular DNA Hydrogels Based on Chemically Branched DNA

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