TY - JOUR
T1 - Short communication
T2 - Sex-linked differences in gamma-aminobutyric acid (GABA) are related to social functioning in autism spectrum disorder
AU - Kirkovski, Melissa
AU - Suo, Chao
AU - Enticott, Peter Gregory
AU - Yücel, Murat
AU - Fitzgerald, Paul Bernard
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/4/30
Y1 - 2018/4/30
N2 - Magnetic resonance spectroscopy (MRS) was utilized to investigate sex differences in gamma-aminobutyric acid (GABA) between adults with autism spectrum disorder (ASD) and neurotypical (NT) controls. GABA at the right superior temporal sulcus (STS) is reported for 12 ASD and 14 NT participants. The results show no group differences in GABA. There was, however, a significant positive association between GABA at the STS and autism-related social impairments in females with ASD. These findings provide preliminary support for sex differences in GABAergic distribution and processes that contribute to social functioning in ASD.
AB - Magnetic resonance spectroscopy (MRS) was utilized to investigate sex differences in gamma-aminobutyric acid (GABA) between adults with autism spectrum disorder (ASD) and neurotypical (NT) controls. GABA at the right superior temporal sulcus (STS) is reported for 12 ASD and 14 NT participants. The results show no group differences in GABA. There was, however, a significant positive association between GABA at the STS and autism-related social impairments in females with ASD. These findings provide preliminary support for sex differences in GABAergic distribution and processes that contribute to social functioning in ASD.
KW - Autism spectrum disorder
KW - Magnetic resonance spectroscopy
KW - Superior temporal sulcus
UR - http://www.scopus.com/inward/record.url?scp=85042519295&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2018.02.004
DO - 10.1016/j.pscychresns.2018.02.004
M3 - Article
SN - 0925-4927
VL - 274
SP - 19
EP - 22
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
ER -