SiLEncing SLE: The power and promise of small noncoding RNAs

Robert J. Rigby; Carola G. Vinuesa

doi:10.1097/BOR.0b013e328304b45e

SiLEncing SLE: The power and promise of small noncoding RNAs

Robert J. Rigby, Carola G. Vinuesa

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Dysregulation of the RNA silencing machinery has been implicated in systemic lupus erythematosus pathogenesis. Although microRNA profiling may prove to be a useful diagnostic and prognostic tool for a notoriously heterogeneous disease, manipulation of RNA interference emerges as a powerful and potentially specific means to correct dysregulated gene expression in systemic lupus erythematosus patients.

Original language	English
Pages (from-to)	526-531
Number of pages	6
Journal	Current Opinion in Rheumatology
Volume	20
Issue number	5
DOIs	https://doi.org/10.1097/BOR.0b013e328304b45e
Publication status	Published - Sept 2008

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title = "SiLEncing SLE: The power and promise of small noncoding RNAs",

abstract = "Dysregulation of the RNA silencing machinery has been implicated in systemic lupus erythematosus pathogenesis. Although microRNA profiling may prove to be a useful diagnostic and prognostic tool for a notoriously heterogeneous disease, manipulation of RNA interference emerges as a powerful and potentially specific means to correct dysregulated gene expression in systemic lupus erythematosus patients.",

keywords = "Micro RNA, Roquin, Small interfering RNA, Small noncoding RNA, Systemic lupus erythematosus",

author = "Rigby, {Robert J.} and Vinuesa, {Carola G.}",

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T2 - The power and promise of small noncoding RNAs

AU - Rigby, Robert J.

AU - Vinuesa, Carola G.

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N2 - Dysregulation of the RNA silencing machinery has been implicated in systemic lupus erythematosus pathogenesis. Although microRNA profiling may prove to be a useful diagnostic and prognostic tool for a notoriously heterogeneous disease, manipulation of RNA interference emerges as a powerful and potentially specific means to correct dysregulated gene expression in systemic lupus erythematosus patients.

AB - Dysregulation of the RNA silencing machinery has been implicated in systemic lupus erythematosus pathogenesis. Although microRNA profiling may prove to be a useful diagnostic and prognostic tool for a notoriously heterogeneous disease, manipulation of RNA interference emerges as a powerful and potentially specific means to correct dysregulated gene expression in systemic lupus erythematosus patients.

KW - Micro RNA

KW - Roquin

KW - Small interfering RNA

KW - Small noncoding RNA

KW - Systemic lupus erythematosus

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U2 - 10.1097/BOR.0b013e328304b45e

DO - 10.1097/BOR.0b013e328304b45e

M3 - Review article

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VL - 20

SP - 526

EP - 531

JO - Current Opinion in Rheumatology

JF - Current Opinion in Rheumatology

IS - 5

ER -

SiLEncing SLE: The power and promise of small noncoding RNAs

Abstract

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