Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre

Tom N. Lea-Henry; Simon H. Jiang

doi:10.21037/atm.2016.11.76

Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre

Tom N. Lea-Henry, Simon H. Jiang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Yamamoto et al. have studied T follicular helper (T_FH) and germinal centre (GC) responses after infection of rhesus macaques (RM) infected with simian immunodeficiency virus (SIV). In this study the authors examined the behaviour of T_FH, reproducing infection-associated T_FH accumulation and their association with the quality of antibody responses against cross-clade viral epitopes. The authors correlate T_FH IL4 and CD154 expression with superior antibody responses. Accumulation of T_FH was accompanied by aberrant expression of non-T_FH transcriptional regulators such as BLIMP1 in T_FH, suggesting viral induced abnormalities may affect T_FH function.

Original language	English
Article number	520
Journal	Annals of Translational Medicine
Volume	4
Issue number	24
DOIs	https://doi.org/10.21037/atm.2016.11.76
Publication status	Published - Dec 2016

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title = "Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre",

abstract = "Yamamoto et al. have studied T follicular helper (TFH) and germinal centre (GC) responses after infection of rhesus macaques (RM) infected with simian immunodeficiency virus (SIV). In this study the authors examined the behaviour of TFH, reproducing infection-associated TFH accumulation and their association with the quality of antibody responses against cross-clade viral epitopes. The authors correlate TFH IL4 and CD154 expression with superior antibody responses. Accumulation of TFH was accompanied by aberrant expression of non-TFH transcriptional regulators such as BLIMP1 in TFH, suggesting viral induced abnormalities may affect TFH function.",

keywords = "Antibody, Germinal centre (GC), Human immunodeficiency virus (HIV), Simian immunodeficiency virus (SIV), T follicular helper cells",

author = "Lea-Henry, {Tom N.} and Jiang, {Simon H.}",

year = "2016",

month = dec,

doi = "10.21037/atm.2016.11.76",

language = "English",

volume = "4",

journal = "Annals of Translational Medicine",

issn = "2305-5839",

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T1 - Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre

AU - Lea-Henry, Tom N.

AU - Jiang, Simon H.

PY - 2016/12

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N2 - Yamamoto et al. have studied T follicular helper (TFH) and germinal centre (GC) responses after infection of rhesus macaques (RM) infected with simian immunodeficiency virus (SIV). In this study the authors examined the behaviour of TFH, reproducing infection-associated TFH accumulation and their association with the quality of antibody responses against cross-clade viral epitopes. The authors correlate TFH IL4 and CD154 expression with superior antibody responses. Accumulation of TFH was accompanied by aberrant expression of non-TFH transcriptional regulators such as BLIMP1 in TFH, suggesting viral induced abnormalities may affect TFH function.

AB - Yamamoto et al. have studied T follicular helper (TFH) and germinal centre (GC) responses after infection of rhesus macaques (RM) infected with simian immunodeficiency virus (SIV). In this study the authors examined the behaviour of TFH, reproducing infection-associated TFH accumulation and their association with the quality of antibody responses against cross-clade viral epitopes. The authors correlate TFH IL4 and CD154 expression with superior antibody responses. Accumulation of TFH was accompanied by aberrant expression of non-TFH transcriptional regulators such as BLIMP1 in TFH, suggesting viral induced abnormalities may affect TFH function.

KW - Antibody

KW - Germinal centre (GC)

KW - Human immunodeficiency virus (HIV)

KW - Simian immunodeficiency virus (SIV)

KW - T follicular helper cells

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DO - 10.21037/atm.2016.11.76

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VL - 4

JO - Annals of Translational Medicine

JF - Annals of Translational Medicine

IS - 24

M1 - 520

ER -

Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre

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