Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

R. A. Kirian; S. Awel; N. Eckerskorn; H. Fleckenstein; M. Wiedorn; L. Adriano; S. Bajt; M. Barthelmess; R. Bean; K. R. Beyerlein; L. M.G. Chavas; M. Domaracky; M. Heymann; D. A. Horke; J. Knoska; M. Metz; A. Morgan; D. Oberthuer; N. Roth; T. Sato; P. L. Xavier; O. Yefanov; A. V. Rode; J. Küpper; H. N. Chapman

doi:10.1063/1.4922648

Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

R. A. Kirian, S. Awel, N. Eckerskorn, H. Fleckenstein, M. Wiedorn, L. Adriano, S. Bajt, M. Barthelmess, R. Bean, K. R. Beyerlein, L. M.G. Chavas, M. Domaracky, M. Heymann, D. A. Horke, J. Knoska, M. Metz, A. Morgan, D. Oberthuer, N. Roth, T. SatoP. L. Xavier, O. Yefanov, A. V. Rode, J. Küpper, H. N. Chapman

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29 Citations (Scopus)

Abstract

A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.

Original language	English
Article number	041717
Journal	Structural Dynamics
Volume	2
Issue number	4
DOIs	https://doi.org/10.1063/1.4922648
Publication status	Published - 1 Jul 2015

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Kirian, R. A., Awel, S., Eckerskorn, N., Fleckenstein, H., Wiedorn, M., Adriano, L., Bajt, S., Barthelmess, M., Bean, R., Beyerlein, K. R., Chavas, L. M. G., Domaracky, M., Heymann, M., Horke, D. A., Knoska, J., Metz, M., Morgan, A., Oberthuer, D., Roth, N., ... Chapman, H. N. (2015). Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers. Structural Dynamics, 2(4), Article 041717. https://doi.org/10.1063/1.4922648

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title = "Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers",

abstract = "A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.",

author = "Kirian, \{R. A.\} and S. Awel and N. Eckerskorn and H. Fleckenstein and M. Wiedorn and L. Adriano and S. Bajt and M. Barthelmess and R. Bean and Beyerlein, \{K. R.\} and Chavas, \{L. M.G.\} and M. Domaracky and M. Heymann and Horke, \{D. A.\} and J. Knoska and M. Metz and A. Morgan and D. Oberthuer and N. Roth and T. Sato and Xavier, \{P. L.\} and O. Yefanov and Rode, \{A. V.\} and J. K{\"u}pper and Chapman, \{H. N.\}",

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year = "2015",

month = jul,

day = "1",

doi = "10.1063/1.4922648",

language = "English",

volume = "2",

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Kirian, RA, Awel, S, Eckerskorn, N, Fleckenstein, H, Wiedorn, M, Adriano, L, Bajt, S, Barthelmess, M, Bean, R, Beyerlein, KR, Chavas, LMG, Domaracky, M, Heymann, M, Horke, DA, Knoska, J, Metz, M, Morgan, A, Oberthuer, D, Roth, N, Sato, T, Xavier, PL, Yefanov, O, Rode, AV, Küpper, J & Chapman, HN 2015, 'Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers', Structural Dynamics, vol. 2, no. 4, 041717. https://doi.org/10.1063/1.4922648

TY - JOUR

T1 - Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

AU - Kirian, R. A.

AU - Awel, S.

AU - Eckerskorn, N.

AU - Fleckenstein, H.

AU - Wiedorn, M.

AU - Adriano, L.

AU - Bajt, S.

AU - Barthelmess, M.

AU - Bean, R.

AU - Beyerlein, K. R.

AU - Chavas, L. M.G.

AU - Domaracky, M.

AU - Heymann, M.

AU - Horke, D. A.

AU - Knoska, J.

AU - Metz, M.

AU - Morgan, A.

AU - Oberthuer, D.

AU - Roth, N.

AU - Sato, T.

AU - Xavier, P. L.

AU - Yefanov, O.

AU - Rode, A. V.

AU - Küpper, J.

AU - Chapman, H. N.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.

AB - A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.

UR - https://www.scopus.com/pages/publications/84944080576

U2 - 10.1063/1.4922648

DO - 10.1063/1.4922648

M3 - Article

SN - 2329-7778

VL - 2

JO - Structural Dynamics

JF - Structural Dynamics

IS - 4

M1 - 041717

ER -

Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

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