Simultaneous mendelian and clonal genome transmission in a sexually reproducing, all-triploid vertebrate

Matthias Stöck, Jana Ustinova, Caroline Betto-Colliard, Manfred Schartl, Craig Moritz, Nicolas Perrin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Meiosis in triploids faces the seemingly insuperable difficulty of dividing an odd number of chromosome sets by two. Triploid vertebrates usually circumvent this problem through either asexuality or some forms of hybridogenesis, including meiotic hybridogenesis that involve a reproductive community of different ploidy levels and genome composition. Batura toads (Bufo baturae; 3n = 33 chromosomes), however, present an all-triploid sexual reproduction. This hybrid species has two genome copies carrying a nucleolus-organizing region (NOR-) on chromosome 6, and a third copy without it (NOR+). Males only produce haploid NOR+ sperm, while ova are diploid, containing one NOR+ and one NOR- set. Here, we conduct sibship analyses with co-dominant microsatellite markers so as (i) to confirm the purely clonal and maternal transmission of the NOR- set, and (ii) to demonstrate Mendelian segregation and recombination of the NOR+ sets in both sexes. This new reproductive mode in vertebrates ('pre-equalizing hybrid meiosis') offers an ideal opportunity to study the evolution of non-recombining genomes. Elucidating the mechanisms that allow simultaneous transmission of two genomes, one of Mendelian, the other of clonal inheritance, might shed light on the general processes that regulate meiosis in vertebrates.

Original languageEnglish
Pages (from-to)1293-1299
Number of pages7
JournalProceedings of the Royal Society B: Biological Sciences
Volume279
Issue number1732
DOIs
Publication statusPublished - 7 Apr 2012
Externally publishedYes

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