Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer

João D. Barros-Silva; Douglas E. Linn; Ivana Steiner; Guoji Guo; Adnan Ali; Hubert Pakula; Garry Ashton; Isabel Peset; Michael Brown; Noel W. Clarke; Roderick T. Bronson; Guo Cheng Yuan; Stuart H. Orkin; Zhe Li; Esther Baena

doi:10.1016/j.celrep.2018.11.069

Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer

João D. Barros-Silva, Douglas E. Linn, Ivana Steiner, Guoji Guo, Adnan Ali, Hubert Pakula, Garry Ashton, Isabel Peset, Michael Brown, Noel W. Clarke, Roderick T. Bronson, Guo Cheng Yuan, Stuart H. Orkin^*, Zhe Li, Esther Baena

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

To address the identity of castration-resistant prostate cells in vivo, Barros-Silva et al. coupled single-cell analysis with organoid culture and in situ lineage tracing. They identify LY6D as a progenitor marker that liaises intrinsically castration-resistant luminal cells and castration-resistant prostate tumor growth.

Original language	English
Pages (from-to)	3504-3518.e6
Journal	Cell Reports
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2018.11.069
Publication status	Published - 18 Dec 2018
Externally published	Yes

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10.1016/j.celrep.2018.11.069

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Barros-Silva, J. D., Linn, D. E., Steiner, I., Guo, G., Ali, A., Pakula, H., Ashton, G., Peset, I., Brown, M., Clarke, N. W., Bronson, R. T., Yuan, G. C., Orkin, S. H., Li, Z., & Baena, E. (2018). Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Reports, 25(12), 3504-3518.e6. https://doi.org/10.1016/j.celrep.2018.11.069

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title = "Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer",

abstract = "To address the identity of castration-resistant prostate cells in vivo, Barros-Silva et al. coupled single-cell analysis with organoid culture and in situ lineage tracing. They identify LY6D as a progenitor marker that liaises intrinsically castration-resistant luminal cells and castration-resistant prostate tumor growth.",

keywords = "castration-resistant prostate cancer, intrinsic resistance, luminal progenitor, LY6D, tumor-initiating cells",

author = "Barros-Silva, {Jo{\~a}o D.} and Linn, {Douglas E.} and Ivana Steiner and Guoji Guo and Adnan Ali and Hubert Pakula and Garry Ashton and Isabel Peset and Michael Brown and Clarke, {Noel W.} and Bronson, {Roderick T.} and Yuan, {Guo Cheng} and Orkin, {Stuart H.} and Zhe Li and Esther Baena",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

month = dec,

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doi = "10.1016/j.celrep.2018.11.069",

language = "English",

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Barros-Silva, JD, Linn, DE, Steiner, I, Guo, G, Ali, A, Pakula, H, Ashton, G, Peset, I, Brown, M, Clarke, NW, Bronson, RT, Yuan, GC, Orkin, SH, Li, Z & Baena, E 2018, 'Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer', Cell Reports, vol. 25, no. 12, pp. 3504-3518.e6. https://doi.org/10.1016/j.celrep.2018.11.069

TY - JOUR

T1 - Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer

AU - Barros-Silva, João D.

AU - Linn, Douglas E.

AU - Steiner, Ivana

AU - Guo, Guoji

AU - Ali, Adnan

AU - Pakula, Hubert

AU - Ashton, Garry

AU - Peset, Isabel

AU - Brown, Michael

AU - Clarke, Noel W.

AU - Bronson, Roderick T.

AU - Yuan, Guo Cheng

AU - Orkin, Stuart H.

AU - Li, Zhe

AU - Baena, Esther

PY - 2018/12/18

Y1 - 2018/12/18

N2 - To address the identity of castration-resistant prostate cells in vivo, Barros-Silva et al. coupled single-cell analysis with organoid culture and in situ lineage tracing. They identify LY6D as a progenitor marker that liaises intrinsically castration-resistant luminal cells and castration-resistant prostate tumor growth.

AB - To address the identity of castration-resistant prostate cells in vivo, Barros-Silva et al. coupled single-cell analysis with organoid culture and in situ lineage tracing. They identify LY6D as a progenitor marker that liaises intrinsically castration-resistant luminal cells and castration-resistant prostate tumor growth.

KW - castration-resistant prostate cancer

KW - intrinsic resistance

KW - luminal progenitor

KW - LY6D

KW - tumor-initiating cells

UR - http://www.scopus.com/inward/record.url?scp=85058168580&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2018.11.069

DO - 10.1016/j.celrep.2018.11.069

M3 - Article

C2 - 30566873

AN - SCOPUS:85058168580

SN - 2211-1247

VL - 25

SP - 3504-3518.e6

JO - Cell Reports

JF - Cell Reports

IS - 12

ER -

Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer

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