Small zinc doped iron oxide tracers for magnetic particle imaging

H. T. Kim Duong; Ashkan Abdibastami; Lucy Gloag; Andre Bongers; Saeed Shanehsazzadeh; Melanie Nelson; Aidan Cousins; Narges Bayat; Hannah Mccalmont; Richard B. Lock; Scott Sulway; Joanna Biazick; J. Justin Gooding; Richard D. Tilley

doi:10.1016/j.jmmm.2023.171304

Small zinc doped iron oxide tracers for magnetic particle imaging

H. T. Kim Duong, Ashkan Abdibastami, Lucy Gloag, Andre Bongers, Saeed Shanehsazzadeh, Melanie Nelson, Aidan Cousins, Narges Bayat, Hannah Mccalmont, Richard B. Lock, Scott Sulway, Joanna Biazick, J. Justin Gooding, Richard D. Tilley

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Magnetic particle imaging (MPI) has garnered significant attention in biomedical imaging research due to its excellent signal intensity that is generated directly from superparamagnetic iron oxide nanoparticles (SPIONs). Small nanoparticle tracers with high saturation magnetisation are crucial for MPI as they can prolong circulation, crossing the blood brain barrier and enhance cellular uptake. In this work, we demonstrate small zinc doped iron oxide nanoparticles (Zn-IONPs) are excellent MPI tracers. Our Zn-IONPs exhibited up to 37 % and 64% enhancement in saturation magnetisation (Msat) value and MPI signal intensity respectively compared to Fe₃O₄ of the same size. As a result, the polymer encapsulated Zn-IONPs achieved up to 2.7-fold enhancement in MPI signal intensity compared to VivoTrax. Furthermore, these polymer encapsulated NPs were also determined to be non-toxic hence making these Zn-IONPs ideal for many biomedical applications in MPI where small size is critical to prolong circulation time and crossing the blood brain barrier.

Original language	English
Article number	171304
Number of pages	7
Journal	Journal of Magnetism and Magnetic Materials
Volume	587
Early online date	Sept 2023
DOIs	https://doi.org/10.1016/j.jmmm.2023.171304
Publication status	Published - 1 Dec 2023
Externally published	Yes

Access to Document

10.1016/j.jmmm.2023.171304

Cite this

Duong, H. T. K., Abdibastami, A., Gloag, L., Bongers, A., Shanehsazzadeh, S., Nelson, M., Cousins, A., Bayat, N., Mccalmont, H., Lock, R. B., Sulway, S., Biazick, J., Gooding, J. J., & Tilley, R. D. (2023). Small zinc doped iron oxide tracers for magnetic particle imaging. Journal of Magnetism and Magnetic Materials, 587, Article 171304. https://doi.org/10.1016/j.jmmm.2023.171304

@article{3849f59f55f0428b8a80918231ce7758,

title = "Small zinc doped iron oxide tracers for magnetic particle imaging",

abstract = "Magnetic particle imaging (MPI) has garnered significant attention in biomedical imaging research due to its excellent signal intensity that is generated directly from superparamagnetic iron oxide nanoparticles (SPIONs). Small nanoparticle tracers with high saturation magnetisation are crucial for MPI as they can prolong circulation, crossing the blood brain barrier and enhance cellular uptake. In this work, we demonstrate small zinc doped iron oxide nanoparticles (Zn-IONPs) are excellent MPI tracers. Our Zn-IONPs exhibited up to 37 % and 64% enhancement in saturation magnetisation (Msat) value and MPI signal intensity respectively compared to Fe3O4 of the same size. As a result, the polymer encapsulated Zn-IONPs achieved up to 2.7-fold enhancement in MPI signal intensity compared to VivoTrax. Furthermore, these polymer encapsulated NPs were also determined to be non-toxic hence making these Zn-IONPs ideal for many biomedical applications in MPI where small size is critical to prolong circulation time and crossing the blood brain barrier.",

keywords = "Nanoparticles, Size",

author = "Duong, {H. T. Kim} and Ashkan Abdibastami and Lucy Gloag and Andre Bongers and Saeed Shanehsazzadeh and Melanie Nelson and Aidan Cousins and Narges Bayat and Hannah Mccalmont and Lock, {Richard B.} and Scott Sulway and Joanna Biazick and Gooding, {J. Justin} and Tilley, {Richard D.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = dec,

day = "1",

doi = "10.1016/j.jmmm.2023.171304",

language = "English",

volume = "587",

journal = "Journal of Magnetism and Magnetic Materials",

issn = "0304-8853",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Small zinc doped iron oxide tracers for magnetic particle imaging

AU - Duong, H. T. Kim

AU - Abdibastami, Ashkan

AU - Gloag, Lucy

AU - Bongers, Andre

AU - Shanehsazzadeh, Saeed

AU - Nelson, Melanie

AU - Cousins, Aidan

AU - Bayat, Narges

AU - Mccalmont, Hannah

AU - Lock, Richard B.

AU - Sulway, Scott

AU - Biazick, Joanna

AU - Gooding, J. Justin

AU - Tilley, Richard D.

PY - 2023/12/1

Y1 - 2023/12/1

N2 - Magnetic particle imaging (MPI) has garnered significant attention in biomedical imaging research due to its excellent signal intensity that is generated directly from superparamagnetic iron oxide nanoparticles (SPIONs). Small nanoparticle tracers with high saturation magnetisation are crucial for MPI as they can prolong circulation, crossing the blood brain barrier and enhance cellular uptake. In this work, we demonstrate small zinc doped iron oxide nanoparticles (Zn-IONPs) are excellent MPI tracers. Our Zn-IONPs exhibited up to 37 % and 64% enhancement in saturation magnetisation (Msat) value and MPI signal intensity respectively compared to Fe3O4 of the same size. As a result, the polymer encapsulated Zn-IONPs achieved up to 2.7-fold enhancement in MPI signal intensity compared to VivoTrax. Furthermore, these polymer encapsulated NPs were also determined to be non-toxic hence making these Zn-IONPs ideal for many biomedical applications in MPI where small size is critical to prolong circulation time and crossing the blood brain barrier.

AB - Magnetic particle imaging (MPI) has garnered significant attention in biomedical imaging research due to its excellent signal intensity that is generated directly from superparamagnetic iron oxide nanoparticles (SPIONs). Small nanoparticle tracers with high saturation magnetisation are crucial for MPI as they can prolong circulation, crossing the blood brain barrier and enhance cellular uptake. In this work, we demonstrate small zinc doped iron oxide nanoparticles (Zn-IONPs) are excellent MPI tracers. Our Zn-IONPs exhibited up to 37 % and 64% enhancement in saturation magnetisation (Msat) value and MPI signal intensity respectively compared to Fe3O4 of the same size. As a result, the polymer encapsulated Zn-IONPs achieved up to 2.7-fold enhancement in MPI signal intensity compared to VivoTrax. Furthermore, these polymer encapsulated NPs were also determined to be non-toxic hence making these Zn-IONPs ideal for many biomedical applications in MPI where small size is critical to prolong circulation time and crossing the blood brain barrier.

KW - Nanoparticles

KW - Size

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=anu_research_portal_plus2&SrcAuth=WosAPI&KeyUT=WOS:001088980000001&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1016/j.jmmm.2023.171304

DO - 10.1016/j.jmmm.2023.171304

M3 - Article

AN - SCOPUS:85172710658

SN - 0304-8853

VL - 587

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

M1 - 171304

ER -

Small zinc doped iron oxide tracers for magnetic particle imaging

Abstract

Access to Document

Other files and links

Fingerprint

Cite this