Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke

Mohammad Al-Tamimi; Elizabeth E. Gardiner; Jim Y. Thom; Yang Shen; Matthew N. Cooper; Graeme J. Hankey; Michael C. Berndt; Ross I. Baker; Robert K. Andrews

doi:10.1161/STROKEAHA.110.602532

Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke

Mohammad Al-Tamimi^*, Elizabeth E. Gardiner, Jim Y. Thom, Yang Shen, Matthew N. Cooper, Graeme J. Hankey, Michael C. Berndt, Ross I. Baker, Robert K. Andrews

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Background and Purpose- Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding. Methods- We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects. Results- sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024). CONCLUSION-: Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.

Original language	English
Pages (from-to)	498-500
Number of pages	3
Journal	Stroke
Volume	42
Issue number	2
DOIs	https://doi.org/10.1161/STROKEAHA.110.602532
Publication status	Published - Feb 2011
Externally published	Yes

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10.1161/STROKEAHA.110.602532

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title = "Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke",

abstract = "Background and Purpose- Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding. Methods- We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects. Results- sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024). CONCLUSION-: Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.",

keywords = "GPVI, platelets, stroke",

author = "Mohammad Al-Tamimi and Gardiner, {Elizabeth E.} and Thom, {Jim Y.} and Yang Shen and Cooper, {Matthew N.} and Hankey, {Graeme J.} and Berndt, {Michael C.} and Baker, {Ross I.} and Andrews, {Robert K.}",

year = "2011",

month = feb,

doi = "10.1161/STROKEAHA.110.602532",

language = "English",

volume = "42",

pages = "498--500",

journal = "Stroke",

issn = "0039-2499",

publisher = "American Heart Association",

number = "2",

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T1 - Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke

AU - Al-Tamimi, Mohammad

AU - Gardiner, Elizabeth E.

AU - Thom, Jim Y.

AU - Shen, Yang

AU - Cooper, Matthew N.

AU - Hankey, Graeme J.

AU - Berndt, Michael C.

AU - Baker, Ross I.

AU - Andrews, Robert K.

PY - 2011/2

Y1 - 2011/2

N2 - Background and Purpose- Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding. Methods- We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects. Results- sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024). CONCLUSION-: Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.

AB - Background and Purpose- Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding. Methods- We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects. Results- sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024). CONCLUSION-: Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.

KW - GPVI

KW - platelets

KW - stroke

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U2 - 10.1161/STROKEAHA.110.602532

DO - 10.1161/STROKEAHA.110.602532

M3 - Article

SN - 0039-2499

VL - 42

SP - 498

EP - 500

JO - Stroke

JF - Stroke

IS - 2

ER -

Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke

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