Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke

Mohammad Al-Tamimi*, Elizabeth E. Gardiner, Jim Y. Thom, Yang Shen, Matthew N. Cooper, Graeme J. Hankey, Michael C. Berndt, Ross I. Baker, Robert K. Andrews

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Background and Purpose- Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding. Methods- We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects. Results- sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024). CONCLUSION-: Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.

Original languageEnglish
Pages (from-to)498-500
Number of pages3
JournalStroke
Volume42
Issue number2
DOIs
Publication statusPublished - Feb 2011
Externally publishedYes

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