Solvent-Free Synthesis of Cyanoformamides from Carbamoyl Imidazoles

Jeremy Nugent; Sarah G. Campbell; Yen Vo; Brett D. Schwartz

doi:10.1002/ejoc.201700974

Solvent-Free Synthesis of Cyanoformamides from Carbamoyl Imidazoles

Jeremy Nugent, Sarah G. Campbell, Yen Vo, Brett D. Schwartz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A straightforward and solvent-free synthesis of various secondary and tertiary cyanoformamides from carbamoyl imidazoles and TMSCN has been developed. Both cyclic and acyclic carbamoyl imidazoles react smoothly to form the relevant cyanoformamides in excellent yields, often within minutes.

Original language	English
Pages (from-to)	5110-5118
Number of pages	9
Journal	European Journal of Organic Chemistry
Volume	2017
Issue number	34
DOIs	https://doi.org/10.1002/ejoc.201700974
Publication status	Published - 15 Sept 2017

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abstract = "A straightforward and solvent-free synthesis of various secondary and tertiary cyanoformamides from carbamoyl imidazoles and TMSCN has been developed. Both cyclic and acyclic carbamoyl imidazoles react smoothly to form the relevant cyanoformamides in excellent yields, often within minutes.",

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AU - Vo, Yen

AU - Schwartz, Brett D.

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Y1 - 2017/9/15

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AB - A straightforward and solvent-free synthesis of various secondary and tertiary cyanoformamides from carbamoyl imidazoles and TMSCN has been developed. Both cyclic and acyclic carbamoyl imidazoles react smoothly to form the relevant cyanoformamides in excellent yields, often within minutes.

KW - Cyanides

KW - Green chemistry

KW - Imidazoles

KW - Synthesis design

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JF - European Journal of Organic Chemistry

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Solvent-Free Synthesis of Cyanoformamides from Carbamoyl Imidazoles

Abstract

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