Species variability in cardiovascular research: The example of adrenocorticotrophin-induced hypertension

Judith A. Whitworth; Yi Zhang; George Mangos; John J. Kelly

doi:10.1111/j.1440-1681.2006.04460.x

Species variability in cardiovascular research: The example of adrenocorticotrophin-induced hypertension

Judith A. Whitworth^*, Yi Zhang, George Mangos, John J. Kelly

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.

Original language	English
Pages (from-to)	887-891
Number of pages	5
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	33
Issue number	9
DOIs	https://doi.org/10.1111/j.1440-1681.2006.04460.x
Publication status	Published - Sept 2006

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Cite this

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abstract = "1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.",

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AU - Mangos, George

AU - Kelly, John J.

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KW - Blood pressure

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KW - Humans

KW - Mouse

KW - Rat

KW - Sheep

KW - Steroids

UR - https://www.scopus.com/pages/publications/33747051730

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M3 - Article

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JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

IS - 9

ER -

Species variability in cardiovascular research: The example of adrenocorticotrophin-induced hypertension

Abstract

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