Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

Lena J. Daumann; Gerhard Schenk; David L. Ollis; Lawrence R. Gahan

doi:10.1039/c3dt52287c

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

Lena J. Daumann, Gerhard Schenk, David L. Ollis, Lawrence R. Gahan^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

66 Citations (Scopus)

Abstract

An enhanced understanding of the metal ion binding and active site structural features of phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ), and the organophosphate degrading agent from Agrobacterium radiobacter (OpdA) have important consequences for potential applications. Coupled with investigations of the metalloenzymes, programs of study to synthesise and characterise model complexes based on these metalloenzymes can add to our understanding of structure and function of the enzymes themselves. This review summarises some of our work and illustrates the significance and contributions of model studies to knowledge in the area.

Original language	English
Pages (from-to)	910-928
Number of pages	19
Journal	Dalton Transactions
Volume	43
Issue number	3
DOIs	https://doi.org/10.1039/c3dt52287c
Publication status	Published - 21 Jan 2014

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abstract = "An enhanced understanding of the metal ion binding and active site structural features of phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ), and the organophosphate degrading agent from Agrobacterium radiobacter (OpdA) have important consequences for potential applications. Coupled with investigations of the metalloenzymes, programs of study to synthesise and characterise model complexes based on these metalloenzymes can add to our understanding of structure and function of the enzymes themselves. This review summarises some of our work and illustrates the significance and contributions of model studies to knowledge in the area.",

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AU - Daumann, Lena J.

AU - Schenk, Gerhard

AU - Ollis, David L.

AU - Gahan, Lawrence R.

PY - 2014/1/21

Y1 - 2014/1/21

N2 - An enhanced understanding of the metal ion binding and active site structural features of phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ), and the organophosphate degrading agent from Agrobacterium radiobacter (OpdA) have important consequences for potential applications. Coupled with investigations of the metalloenzymes, programs of study to synthesise and characterise model complexes based on these metalloenzymes can add to our understanding of structure and function of the enzymes themselves. This review summarises some of our work and illustrates the significance and contributions of model studies to knowledge in the area.

AB - An enhanced understanding of the metal ion binding and active site structural features of phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ), and the organophosphate degrading agent from Agrobacterium radiobacter (OpdA) have important consequences for potential applications. Coupled with investigations of the metalloenzymes, programs of study to synthesise and characterise model complexes based on these metalloenzymes can add to our understanding of structure and function of the enzymes themselves. This review summarises some of our work and illustrates the significance and contributions of model studies to knowledge in the area.

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U2 - 10.1039/c3dt52287c

DO - 10.1039/c3dt52287c

M3 - Review article

SN - 1477-9226

VL - 43

SP - 910

EP - 928

JO - Dalton Transactions

JF - Dalton Transactions

IS - 3

ER -

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

Abstract

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