Spontaneous spatial navigation circuitry in schizophrenia spectrum disorders

Leanne K. Wilkins, Todd A. Girard*, Bruce K. Christensen, Jelena King, Michael Kiang, Veronique D. Bohbot

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Spatial memory is core to wayfinding and everyday memory. Interestingly, individuals with schizophrenia using spatial navigation strategies (cognitive mapping)are impaired, whereas those using response-based (e.g., single-landmark)strategies show relatively intact memory performance. We observed abnormal brain communication in schizophrenia participants who used a spatial strategy during a virtual-reality navigation task, particularly between temporal and frontal brain regions. In contrast, schizophrenia participants using a response strategy recruited similar brain systems to healthy participants, but to a greater extent to support memory performance. These findings highlight that strategy use is an important consideration for understanding memory systems and navigation in schizophrenia.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalPsychiatry Research
Publication statusPublished - Aug 2019
Externally publishedYes


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