Stable isotope abundance and fractionation in human diseases

Illa Tea; Arnaud De Luca; Anne Marie Schiphorst; Mathilde Grand; Sophie Barillé-Nion; Eric Mirallié; Delphine Drui; Michel Krempf; Régis Hankard; Guillaume Tcherkez

doi:10.3390/metabo11060370

Stable isotope abundance and fractionation in human diseases

Illa Tea^*, Arnaud De Luca, Anne Marie Schiphorst, Mathilde Grand, Sophie Barillé-Nion, Eric Mirallié, Delphine Drui, Michel Krempf, Régis Hankard, Guillaume Tcherkez

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Abstract

The natural abundance of heavy stable isotopes (¹³ C,¹⁵ N,¹⁸ O, etc.) is now of considerable importance in many research fields, including human physiology. In fact, it varies between tissues and metabolites due to isotope effects in biological processes, that is, isotope discriminations between heavy and light isotopic forms during enzyme or transporter activity. The metabolic deregulation associated with many diseases leads to alterations in metabolic fluxes, resulting in changes in isotope abundance that can be identified easily with current isotope ratio technologies. In this review, we summarize the current knowledge on changes in natural isotope composition in samples (including various tissues, hair, plasma, saliva) found in patients compared to controls, caused by human diseases. We discuss the metabolic origin of such isotope fractionations and highlight the potential of using isotopes at natural abundance for medical diagnosis and/or prognostic.

Original language	English
Article number	370
Journal	Metabolites
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/metabo11060370
Publication status	Published - Jun 2021

Access to Document

10.3390/metabo11060370

Cite this

@article{ccc399077e8945f0ac932caff63a9338,

title = "Stable isotope abundance and fractionation in human diseases",

abstract = "The natural abundance of heavy stable isotopes (13 C,15 N,18 O, etc.) is now of considerable importance in many research fields, including human physiology. In fact, it varies between tissues and metabolites due to isotope effects in biological processes, that is, isotope discriminations between heavy and light isotopic forms during enzyme or transporter activity. The metabolic deregulation associated with many diseases leads to alterations in metabolic fluxes, resulting in changes in isotope abundance that can be identified easily with current isotope ratio technologies. In this review, we summarize the current knowledge on changes in natural isotope composition in samples (including various tissues, hair, plasma, saliva) found in patients compared to controls, caused by human diseases. We discuss the metabolic origin of such isotope fractionations and highlight the potential of using isotopes at natural abundance for medical diagnosis and/or prognostic.",

keywords = "Cancer, Diabetes, Fractionation, Isotope effect, Metabolic partitioning, Metal homeostasis",

author = "Illa Tea and {De Luca}, Arnaud and Schiphorst, {Anne Marie} and Mathilde Grand and Sophie Barill{\'e}-Nion and Eric Miralli{\'e} and Delphine Drui and Michel Krempf and R{\'e}gis Hankard and Guillaume Tcherkez",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jun,

doi = "10.3390/metabo11060370",

language = "English",

volume = "11",

journal = "Metabolites",

issn = "2218-1989",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

}

TY - JOUR

T1 - Stable isotope abundance and fractionation in human diseases

AU - Tea, Illa

AU - De Luca, Arnaud

AU - Schiphorst, Anne Marie

AU - Grand, Mathilde

AU - Barillé-Nion, Sophie

AU - Mirallié, Eric

AU - Drui, Delphine

AU - Krempf, Michel

AU - Hankard, Régis

AU - Tcherkez, Guillaume

PY - 2021/6

Y1 - 2021/6

N2 - The natural abundance of heavy stable isotopes (13 C,15 N,18 O, etc.) is now of considerable importance in many research fields, including human physiology. In fact, it varies between tissues and metabolites due to isotope effects in biological processes, that is, isotope discriminations between heavy and light isotopic forms during enzyme or transporter activity. The metabolic deregulation associated with many diseases leads to alterations in metabolic fluxes, resulting in changes in isotope abundance that can be identified easily with current isotope ratio technologies. In this review, we summarize the current knowledge on changes in natural isotope composition in samples (including various tissues, hair, plasma, saliva) found in patients compared to controls, caused by human diseases. We discuss the metabolic origin of such isotope fractionations and highlight the potential of using isotopes at natural abundance for medical diagnosis and/or prognostic.

AB - The natural abundance of heavy stable isotopes (13 C,15 N,18 O, etc.) is now of considerable importance in many research fields, including human physiology. In fact, it varies between tissues and metabolites due to isotope effects in biological processes, that is, isotope discriminations between heavy and light isotopic forms during enzyme or transporter activity. The metabolic deregulation associated with many diseases leads to alterations in metabolic fluxes, resulting in changes in isotope abundance that can be identified easily with current isotope ratio technologies. In this review, we summarize the current knowledge on changes in natural isotope composition in samples (including various tissues, hair, plasma, saliva) found in patients compared to controls, caused by human diseases. We discuss the metabolic origin of such isotope fractionations and highlight the potential of using isotopes at natural abundance for medical diagnosis and/or prognostic.

KW - Cancer

KW - Diabetes

KW - Fractionation

KW - Isotope effect

KW - Metabolic partitioning

KW - Metal homeostasis

UR - http://www.scopus.com/inward/record.url?scp=85108728741&partnerID=8YFLogxK

U2 - 10.3390/metabo11060370

DO - 10.3390/metabo11060370

M3 - Review article

SN - 2218-1989

VL - 11

JO - Metabolites

JF - Metabolites

IS - 6

M1 - 370

ER -

Stable isotope abundance and fractionation in human diseases

Abstract

Access to Document

Other files and links

Fingerprint

Cite this