STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis

Ying Shen, Xiaohong Wang*, Yi Liu, Mahak Singhal, Can Gürkaşlar, Aida Freire Valls, Yi Lei, Wenjie Hu, Géza Schermann, Heike Adler, Fa Xing Yu, Tamás Fischer, Yi Zhu, Hellmut G. Augustin, Thomas Schmidt*, Carmen Ruiz De Almodóvar*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    54 Citations (Scopus)


    The nuclear translocation and activity of the cotranscriptional activators YAP and TAZ (YAP/TAZ) in endothelial cells (ECs) are crucial during developmental angiogenesis. Here, we studied the role of YAP/TAZ signaling in ECs in tumor angiogenesis and found that the expression of YAP/TAZ and downstream target genes in ECs correlated with tumor vascularization in human colorectal carcinomas and skin melanoma. Treatment with the YAP/TAZ inhibitor verteporfin reduced vessel density and tumor progression in a mouse colorectal cancer (CRC) model. Conditional deletion of YAP/TAZ in ECs reduced tumor angiogenesis and growth in a mouse B16-F10 melanoma model. Using cultured ECs and mice with EC-specific ablation, we showed that signal transducer and activator of transcription 3 (STAT3) was required for the activation of YAP/TAZ in tumor-associated ECs. Moreover, we showed that STAT3-mediated signaling promoted YAP/TAZ activity and that the nuclear shuttling machinery for STAT3 was also required for YAP/TAZ nuclear translocation. Together, our data highlight the role of YAP/TAZ as critical players in ECs during tumor angiogenesis and provide insight into the signaling pathways leading to their activation.

    Original languageEnglish
    Article numberabj8393
    JournalScience Signaling
    Issue number712
    Publication statusPublished - 7 Dec 2021


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