Statistical analysis and physical modelling of oligonucleotide microarrays

Conrad J. Burden; Yvonne E. Pittelkow; Susan R. Wilson

doi:10.1007/978-0-8176-4558-8_29

Statistical analysis and physical modelling of oligonucleotide microarrays

Conrad J. Burden, Yvonne E. Pittelkow, Susan R. Wilson

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The inference of regulatory networks from microarray data relies on expression measures to identify gene activity patterns. However, currently existing xpression measures are not the direct measurements of mRNA concentration one would ideally need for an accurate determination of gene regulation. If the development of expression measures is to advance to the point where absolute target concentrations can be estimated, it is essential to have an understanding of physical processes leading to observed microarray data. We survey here the performance of existing expression measures for oligonucleotide microarrays and describe recent progress in developing physical dynamic adsorption models relating measured fluorescent dye intensities to underlying target mRNA concentration.

Original language	English
Title of host publication	Modeling and Simulation in Science, Engineering and Technology
Publisher	Springer Basel
Pages	323-336
Number of pages	14
DOIs	https://doi.org/10.1007/978-0-8176-4558-8_29
Publication status	Published - 2007

Publication series

Name	Modeling and Simulation in Science, Engineering and Technology
Volume	38
ISSN (Print)	2164-3679
ISSN (Electronic)	2164-3725

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10.1007/978-0-8176-4558-8_29

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Statistical analysis and physical modelling of oligonucleotide microarrays. / Burden, Conrad J.; Pittelkow, Yvonne E.; Wilson, Susan R.
Modeling and Simulation in Science, Engineering and Technology. Springer Basel, 2007. p. 323-336 (Modeling and Simulation in Science, Engineering and Technology; Vol. 38).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Pittelkow, Yvonne E.

AU - Wilson, Susan R.

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BT - Modeling and Simulation in Science, Engineering and Technology

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Statistical analysis and physical modelling of oligonucleotide microarrays

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