TY - JOUR
T1 - Status of Blood Levels of Superoxide Dismutase in Patients with Malaria
T2 - A Systematic Review and Meta-Analysis
AU - Kotepui, Kwuntida Uthaisar
AU - Mueangson, Onchuma
AU - Mala, Wanida
AU - Mahittikorn, Aongart
AU - Wangdi, Kinley
AU - Kotepui, Manas
N1 - Publisher Copyright:
© 2024 Mary Ann Liebert Inc.. All rights reserved.
PY - 2024/2
Y1 - 2024/2
N2 - Aims: The evidence of superoxide dismutase (SOD) in the pathogenesis of malaria is inconsistent. This study aimed to synthesize the evidence of blood levels of SOD in patients with malaria and determine the association of blood levels of SOD with the severity of malaria. Results: A total of 1874 articles were retrieved from database searches and 28 studies were included in the review. The blood levels of SOD were lower in individuals with malaria compared with those without malaria infection (p < 0.01, Cohen's d: -2.06, 95% CI: -2.99 to -1.14), I2: 98.96%, 2181 malaria cases/1186 uninfected cases). There were no differences in blood levels of SOD between severe and nonsevere malaria patients (p = 0.09, Cohen's d: -1.57, 95% CI: -3.39 to 0.26), I2: 96.02%, 69 severe malaria cases/256 nonsevere malaria cases). Innovation and Conclusion: The blood levels of SOD were lower in malaria patients compared with those without malaria infection. Further studies will be required to determine the extent to which SOD might prevent Plasmodium infections during pregnancy. Antioxid. Redox Signal. 40, 222-235.
AB - Aims: The evidence of superoxide dismutase (SOD) in the pathogenesis of malaria is inconsistent. This study aimed to synthesize the evidence of blood levels of SOD in patients with malaria and determine the association of blood levels of SOD with the severity of malaria. Results: A total of 1874 articles were retrieved from database searches and 28 studies were included in the review. The blood levels of SOD were lower in individuals with malaria compared with those without malaria infection (p < 0.01, Cohen's d: -2.06, 95% CI: -2.99 to -1.14), I2: 98.96%, 2181 malaria cases/1186 uninfected cases). There were no differences in blood levels of SOD between severe and nonsevere malaria patients (p = 0.09, Cohen's d: -1.57, 95% CI: -3.39 to 0.26), I2: 96.02%, 69 severe malaria cases/256 nonsevere malaria cases). Innovation and Conclusion: The blood levels of SOD were lower in malaria patients compared with those without malaria infection. Further studies will be required to determine the extent to which SOD might prevent Plasmodium infections during pregnancy. Antioxid. Redox Signal. 40, 222-235.
KW - Plasmodium
KW - SOD
KW - complicated
KW - malaria
KW - marker
KW - meta-analysis
KW - severe
KW - superoxide dismutase
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85169154898&partnerID=8YFLogxK
U2 - 10.1089/ars.2023.0273
DO - 10.1089/ars.2023.0273
M3 - Article
SN - 1523-0864
VL - 40
SP - 222
EP - 235
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 4-6
ER -