Stereocontrolled aldol additions to α-methylene-β-alkoxy aldehydes: Application to the synthesis of a C13C25 segment of bafilomycin A1

Ian Paterson*, Shelley Bower, Malcolm D. McLeod

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

A boron-mediated, syn-aldol coupling between ethyl ketone 8 and aldehyde 9, followed by directed hydrogenation at C16 and acetonide hydrolysis, gives the C13C25 segment 6 of bafilomycin A1.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number1
DOIs
Publication statusPublished - 2 Jan 1995
Externally publishedYes

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