Abstract
The use of latent amino acid functionalities for the syntheses of methylidenepiperazine-2,5-diones is reported. These pipérazinediones are potential chiral templates in the synthesis of functionalised piperazinediones and amino acids. Carbon-carbon bond formation utilising radical addition reactions between the methylidenepiperazinediones and a number of alkyl radicals resulted in good yields of the addition adduct. Moderate to high diastereoselectivities \vereobservedandfactorscontrollingthechiralinductionarediscussedhere.
| Original language | English |
|---|---|
| Pages (from-to) | 1173-1182 |
| Number of pages | 10 |
| Journal | Journal of the Chemical Society, Perkin Transactions 1 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1999 |