Stereocontrolled synthesis of (S)-γ-fluoroleucine

Dharshana Padmakshan; Simon A. Bennett; Gottfried Otting; Christopher J. Easton

doi:10.1055/s-2007-977420

Stereocontrolled synthesis of (S)-γ-fluoroleucine

Dharshana Padmakshan, Simon A. Bennett, Gottfried Otting^*, Christopher J. Easton

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Starting with (S)-leucine, the corresponding γ-fluoride 8 has been prepared in a stereocontrolled fashion, by exploiting methods for the direct side-chain bromination of amino acid derivatives and silven(I) fluoride as the fluorinating reagent.

Original language	English
Pages (from-to)	1083-1084
Number of pages	2
Journal	Synlett
Issue number	7
DOIs	https://doi.org/10.1055/s-2007-977420
Publication status	Published - 24 Apr 2007

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title = "Stereocontrolled synthesis of (S)-γ-fluoroleucine",

abstract = "Starting with (S)-leucine, the corresponding γ-fluoride 8 has been prepared in a stereocontrolled fashion, by exploiting methods for the direct side-chain bromination of amino acid derivatives and silven(I) fluoride as the fluorinating reagent.",

keywords = "(S)-γ-fluoroleucine, Amino acids, Halogenation, Silver fluoride, Stereoselective synthesis",

author = "Dharshana Padmakshan and Bennett, {Simon A.} and Gottfried Otting and Easton, {Christopher J.}",

year = "2007",

month = apr,

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doi = "10.1055/s-2007-977420",

language = "English",

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journal = "Synlett",

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AU - Padmakshan, Dharshana

AU - Bennett, Simon A.

AU - Otting, Gottfried

AU - Easton, Christopher J.

PY - 2007/4/24

Y1 - 2007/4/24

N2 - Starting with (S)-leucine, the corresponding γ-fluoride 8 has been prepared in a stereocontrolled fashion, by exploiting methods for the direct side-chain bromination of amino acid derivatives and silven(I) fluoride as the fluorinating reagent.

AB - Starting with (S)-leucine, the corresponding γ-fluoride 8 has been prepared in a stereocontrolled fashion, by exploiting methods for the direct side-chain bromination of amino acid derivatives and silven(I) fluoride as the fluorinating reagent.

KW - (S)-γ-fluoroleucine

KW - Amino acids

KW - Halogenation

KW - Silver fluoride

KW - Stereoselective synthesis

UR - http://www.scopus.com/inward/record.url?scp=34248202056&partnerID=8YFLogxK

U2 - 10.1055/s-2007-977420

DO - 10.1055/s-2007-977420

M3 - Article

SN - 0936-5214

SP - 1083

EP - 1084

JO - Synlett

JF - Synlett

IS - 7

ER -

Stereocontrolled synthesis of (S)-γ-fluoroleucine

Abstract

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