Steroid hormones in Drosophila: how ecdysone coordinates developmental signalling with cell growth and division

Leonie Quinn, Nicola Cranna, Jue Er Amanda Lee, Naomi Mitchell, Jane Lin, Ross Hannan

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    Ecdysone is the major steroid hormone in all holometabolous insects responsible for driving the metamorphosis of larval tissues into adult structures. During metamorphosis, ecdysone is essential for upregulating the genes required to control apoptosis and differentiation, essential processes for removal of larval structures which have become obsolete and for tissue remodelling. In addition, ecdysone directs cell growth and division in many tissues throughout the larval to pupal transition. This chapter will discuss the many diverse mechanisms reported for connecting the ecdysone pulse to the developmentally regulated cell growth and cycle progression required for tissue growth and for insects to reach their target body size.
    Original languageEnglish
    Title of host publicationSteroids - Basic Science
    EditorsHassan Abduljabbar
    Place of PublicationRijeka, Croatia
    PublisherInTech
    Pages141-168
    Volume1
    Edition1st
    ISBN (Print)9789533078663
    DOIs
    Publication statusPublished - 2012

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